Phenotypes associated with this allele

• Allele Symbol: Pik3c3^tm1Tssk
• Allele Name: targeted mutation 1, Takehiko Sasaki
• Allele ID: MGI:5529808
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pik3c3^tm1Tssk/Pik3c3^tm1Tssk Tg(Cryaa-cre)10Mlr/0	involves: FVB/N	MGI:5529810

Genotype
MGI:5529810

cn1

• Allelic Composition: Pik3c3^tm1Tssk/Pik3c3^tm1Tssk; Tg(Cryaa-cre)10Mlr/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cataracts and impaired differentiation of secondary lens fiber cells in Pik3c3^tm1Tssk/Pik3c3^tm1Tssk Tg(Cryaa-cre)10Mlr/0 mice

homeostasis/metabolism

impaired autophagy ( J:198392 )

• inhibited autophagy in the lens at E16

vision/eye

abnormal lens fiber morphology ( J:198392 )

• inhibited autophagy in the lens at E16

• impaired differentiation of secondary lens fiber cells with accumulation of vacuoles

• however, organelle degradation is normal

cataract ( J:198392 )

• bilateral at P0.5

small lens ( J:198392 )

• at P0.5, P7.5 and 2 months

microphthalmia ( J:198392 )

• at birth and more pronounced at 2 months

cellular

impaired autophagy ( J:198392 )

• inhibited autophagy in the lens at E16