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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sp8
trans-acting transcription factor 8
MGI:2443471
22 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+
Tg(Msx2-cre)5Rem/0
involves: 129X1/SvJ * C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:223057
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Sp8tm1Smb/Sp8tm1Smb
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:223057
Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+
Sp8tm1Smb/Sp8tm1Smb
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal autopod morphology J:223057
abnormal limb morphology J:223057
Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+
Sp8tm1Smb/Sp8tm1Smb
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J 		abnormal nasal pit morphology J:200761
decreased cranial neural crest cell proliferation J:200761
increased cranial neural crest cell apoptosis J:200761
increased embryonic neuroepithelium apoptosis J:200761
increased head mesenchyme apoptosis J:200761
lgl/lgl+
Sp8tm1Smb/Sp8+
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 		abnormal craniofacial morphology J:86196
abnormal forelimb morphology J:86196
abnormal hindlimb morphology J:86196
abnormal radius morphology J:86196
abnormal tail morphology J:86196
abnormal ulna morphology J:86196
absent fibula J:86196
absent tibia J:86196
adactyly J:86196
caudal vertebral fusion J:86196
encephalomeningocele J:86196
exencephaly J:86196
incomplete rostral neuropore closure J:86196
perinatal lethality J:86196
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory