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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mcph1
microcephaly, primary autosomal recessive 1
MGI:2443308
66 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Mcph1Gt(RRO608)Byg/Mcph1Gt(RRO608)Byg
involves: 129P2/OlaHsd * C57BL/6
abnormal chromosome morphology J:157993
abnormal mitosis J:157993
decreased survivor rate J:157993
premature death J:157993
normal reproductive system phenotype J:157993
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
involves: C57BL/6
abnormal immune tolerance J:52612
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
NOD.B6-Mcph1Tg(HLA-A2.1)1Enge
increased susceptibility to autoimmune diabetes J:109851
Mcph1Tg(HLA-A2.1)1Enge/Mcph1Tg(HLA-A2.1)1Enge
NOD.B6-Mcph1Tg(HLA-A2.1)1Enge
normal immune system phenotype J:109851
increased susceptibility to autoimmune diabetes J:109851
Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Not Specified
abnormal brain development J:180706
abnormal cell cycle J:180706
abnormal chromosome morphology J:180706
abnormal cortical intermediate zone morphology J:180706
abnormal mitosis J:180706
abnormal mitotic spindle morphology J:180706
abnormal neocortex morphology J:180706
abnormal neuron differentiation J:180706
abnormal neuronal precursor proliferation J:180706
decreased brain size J:180706
increased neuron apoptosis J:180706
infertility J:180706
microcephaly J:180706
ovary atrophy J:180706
testicular atrophy J:180706
thin cerebral cortex J:180706
thin cortical plate J:180706
Mcph1tm1.2Kali/Mcph1tm1.2Kali
involves: 129S7/SvEvBrd * C57BL/6J
abnormal male germ cell apoptosis J:156371
abnormal male meiosis J:156371
abnormal seminiferous tubule morphology J:156371
abnormal spermatid morphology J:156371
abnormal T cell physiology J:156371
absent ovarian follicles J:156371
arrest of male meiosis J:156371
decreased body weight J:156371
decreased male germ cell number J:156371
decreased ovary weight J:156371
female infertility J:156371
increased cellular sensitivity to gamma-irradiation J:156371
increased mortality induced by gamma-irradiation J:156371
induced chromosome breakage J:156371
male infertility J:156371
perinatal lethality, incomplete penetrance J:156371
small testis J:156371
Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi
abnormal cornea morphology J:175295
abnormal eye pigmentation J:175295
absent pinna reflex J:175295
corneal opacity J:175295
corneal vascularization J:175295
decreased body weight J:175295
decreased bone mineral density J:175295
decreased lean body mass J:175295
female infertility J:211773
increased thermal nociceptive threshold J:175295
male infertility J:211773
Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
involves: C57BL/6 * C57BL/6N
abnormal auditory brainstem response J:213427
abnormal cornea morphology J:213427
abnormal corneal stroma morphology J:213427
abnormal eye anterior chamber morphology J:213427
abnormal fertility/fecundity J:213427
abnormal lens morphology J:213427
abnormal reproductive system morphology J:213427
absent pinna reflex J:213427
cataract J:213427
chromosomal instability J:213427
corneal opacity J:213427
corneal vascularization J:213427
decreased bone mineral content J:213427
decreased bone trabecula number J:213427
decreased trabecular bone mass J:213427
decreased trabecular bone volume J:213427
disorganized retinal layers J:213427
increased B cell number J:213427
increased cornea thickness J:213427
microcephaly J:213427
microphthalmia J:213427
persistent hyaloid artery J:213427
small gonad J:213427

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last database update
05/07/2019
MGI 6.14
The Jackson Laboratory