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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Wnk1
WNK lysine deficient protein kinase 1
MGI:2442092
50 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tg(Cdh16-Wnk1*)#Cihu/0
involves: C57BL/6
decreased circulating potassium level J:168700
decreased systemic arterial diastolic blood pressure J:168700
decreased systemic arterial systolic blood pressure J:168700
increased circulating aldosterone level J:168700
increased circulating angiotensinogen level J:168700
increased urine potassium level J:168700
increased urine sodium level J:168700
Wnk1Gt(OST38262)Lex/Wnk1+
involves: 129S5/SvEvBrd * C57BL/6J
decreased systemic arterial blood pressure J:86696
normal homeostasis/metabolism phenotype J:86696
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
involves: 129S5/SvEvBrd
abnormal angiogenesis J:152906
abnormal blood vessel morphology J:152906
abnormal brain vasculature morphology J:152906
abnormal cardinal vein morphology J:152906
abnormal dorsal aorta morphology J:152906
abnormal myocardial trabeculae morphology J:152906
abnormal placenta labyrinth morphology J:152906
abnormal placental labyrinth vasculature morphology J:152906
abnormal vascular branching morphogenesis J:152906
abnormal visceral yolk sac morphology J:152906
abnormal vitelline vascular remodeling J:152906
abnormal vitelline vasculature morphology J:152906
distended pericardium J:152906
embryonic growth retardation J:152906
embryonic lethality during organogenesis, complete penetrance J:152906
heart hemorrhage J:152906
heart hypoplasia J:152906
hemorrhage J:152906
internal hemorrhage J:152906
intracranial hemorrhage J:152906
pale yolk sac J:152906
pericardial edema J:152906
thin myocardium J:152906
trabecula carnea hypoplasia J:152906
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
involves: 129S5/SvEvBrd * C57BL/6J
embryonic lethality during organogenesis, complete penetrance J:86696
Wnk1tm1.1Juha/Wnk1tm1.1Juha
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * SJL
abnormal urine homeostasis J:165537
decreased physiological sensitivity to xenobiotic J:165537
increased mean systemic arterial blood pressure J:165537
increased systemic arterial diastolic blood pressure J:165537
oliguria J:165537
Wnk1tm1Clhu/Wnk1tm1Clhu
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6
abnormal brain vasculature morphology J:152906
abnormal cardinal vein morphology J:152906
abnormal dorsal aorta morphology J:152906
abnormal myocardial trabeculae morphology J:152906
abnormal vascular branching morphogenesis J:152906
abnormal vitelline vascular remodeling J:152906
abnormal vitelline vasculature morphology J:152906
decreased embryo size J:152906
embryonic lethality during organogenesis, complete penetrance J:152906
heart hypoplasia J:152906
pericardial edema J:152906
thin myocardium J:152906
Wnk1tm2.1Juha/Wnk1+
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
abnormal distal convoluted tubule morphology J:200742
abnormal kidney physiology J:200742
decreased hematocrit J:200742
normal homeostasis/metabolism phenotype J:200742
hyperkalemia J:200742
increased circulating chloride level J:200742
increased systemic arterial systolic blood pressure J:200742
increased urine aldosterone level J:200742
increased urine calcium level J:200742
metabolic acidosis J:200742
Wnk1tm2Cihu/Wnk1tm2Cihu
129-Wnk1tm2Cihu
decreased urine sodium level J:168700
increased circulating sodium level J:168700
increased systemic arterial systolic blood pressure J:168700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory