About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
MGI:2384876
43 phenotypes from 3 alleles in 5 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cdc73Gt(RRE190)Byg/Cdc73+
B6.129P2-Cdc73Gt(RRE190)Byg 		abnormal jaw morphology J:243366
abnormal myometrium morphology J:243366
endometrium hyperplasia J:243366
increased activity of parathyroid J:243366
increased circulating calcium level J:243366
increased circulating parathyroid hormone level J:243366
increased parathyroid adenoma incidence J:243366
increased parathyroid gland tumor incidence J:243366
increased uterus tumor incidence J:243366
premature death J:243366
uterus cyst J:243366
Cdc73Gt(RRE190)Byg/Cdc73Gt(RRE190)Byg
involves: 129P2/OlaHsd 		absent inner cell mass proliferation J:135255
absent trophectoderm cell proliferation J:135255
embryonic lethality before implantation, complete penetrance J:135255
failure of embryo implantation J:135255
Cdc73tm1.1Btt/Cdc73tm1.1Btt
involves: 129S4/SvJae * BALB/cJ 		embryonic lethality, complete penetrance J:135255
Cdc73tm1Btt/Cdc73+
Tg(PTH-cre)4167Slib/0
Not Specified 		increased circulating calcium level J:243366
increased parathyroid adenoma incidence J:243366
increased parathyroid gland tumor incidence J:243366
Cdc73tm1Btt/Cdc73tm1Btt
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal digestive system morphology J:135255
abnormal gland physiology J:135255
abnormal nervous system development J:135255
abnormal reflex J:135255
ascites J:135255
decreased abdominal adipose tissue amount J:135255
decreased cell proliferation J:135255
decreased embryo size J:135255
decreased locomotor activity J:135255
decreased pulmonary respiratory rate J:135255
decreased skeletal muscle mass J:135255
decreased subcutaneous adipose tissue amount J:135255
hepatic necrosis J:135255
increased apoptosis J:135255
increased fibroblast apoptosis J:135255
premature death J:135255
prenatal lethality, complete penetrance J:135255
renal necrosis J:135255
small heart J:135255
small kidney J:135255
small liver J:135255
small lung J:135255
small salivary gland J:135255
small seminal vesicle J:135255
small spleen J:135255
small stomach J:135255
small testis J:135255
weight loss J:135255
Cdc73tm1Btt/Cdc73tm1Btt
Tg(PTH-cre)4167Slib/0
Not Specified 		increased circulating calcium level J:243366
increased parathyroid adenoma incidence J:243366
increased parathyroid gland tumor incidence J:243366
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory