About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Sirt1
sirtuin 1
MGI:2135607
48 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Actbtm3.1(Sirt1)Npa/Actb+
involves: 129/Sv * C57BL/6 * C57BL/6J
abnormal motor coordination/balance J:160212
normal behavior/neurological phenotype J:160212
decreased body weight J:160212
decreased circulating adiponectin level J:160212
decreased circulating cholesterol level J:160212
decreased circulating free fatty acid level J:160212
decreased circulating HDL cholesterol level J:160212
decreased circulating insulin level J:160212
decreased circulating LDL cholesterol level J:160212
decreased circulating leptin level J:160212
decreased epididymal fat pad weight J:160212
decreased fasting circulating glucose level J:160212
delayed fertility J:160212
normal homeostasis/metabolism phenotype J:160212
improved glucose tolerance J:160212
increased food intake J:160212
increased oxygen consumption J:160212
preweaning lethality, incomplete penetrance J:160212
Actbtm3.1(Sirt1)Npa/Actb+
Sirt1tm1Mcby/Sirt1tm1Mcby
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J
normal growth/size/body region phenotype J:160212
normal reproductive system phenotype J:160212
normal vision/eye phenotype J:160212
Actbtm3.1(Sirt1)Npa/Actbtm3.1(Sirt1)Npa
involves: 129/Sv * C57BL/6 * C57BL/6J
preweaning lethality, complete penetrance J:160212
ApcMin/Apc+
Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
involves: 129S4/SvJae * C57BL/6 * C57BL/6J
anemia J:134301
cachexia J:134301
increased gastrointestinal tumor incidence J:134301
ApcMin/Apc+
Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Tg(Vil1-cre)997Gum/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
decreased tumor incidence J:134301
Ccar2tm1Dac/Ccar2tm1Dac
Sirt1tm1Ygu/Sirt1tm1Ygu
Tg(SERPINA1-cre)1Arge/0
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
decreased susceptibility to diet-induced obesity J:228688
normal growth/size/body region phenotype J:228688
normal homeostasis/metabolism phenotype J:228688
Ccdc7aTg(Prnp-Sirt1)10Imai/?
B6.Cg-Ccdc7aTg(Prnp-Sirt1)10Imai
abnormal brown adipose tissue physiology J:203814
abnormal neuron physiology J:203814
abnormal non-rapid eye movement sleep pattern J:203814
extended life span J:203814
hyperactivity J:162852, J:203814
hyperactivity elicited by feed restriction J:162852
increased body temperature J:162852, J:203814
increased energy expenditure J:203814
increased food intake J:203814
increased oxygen consumption J:203814
increased vertical activity J:162852
slow aging J:203814
Sirt1tm1.1Cxd/Sirt1+
Trp53tm1Brd/Trp53+
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)
abnormal tumor morphology J:140089
increased carcinoma incidence J:140089
increased lymphoma incidence J:140089
increased sarcoma incidence J:140089
increased teratoma incidence J:140089
increased tumor incidence J:140089
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Trp53tm1Brd/Trp53+
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)
decreased survivor rate J:140089
embryonic lethality, incomplete penetrance J:140089
perinatal lethality, incomplete penetrance J:140089
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Trp53tm1Brd/Trp53tm1Brd
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)
embryonic lethality, incomplete penetrance J:140089
lethality throughout fetal growth and development, incomplete penetrance J:140089
perinatal lethality, incomplete penetrance J:140089
postnatal lethality, complete penetrance J:140089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/12/2019
MGI 6.14
The Jackson Laboratory