Ccar2^tm1Dac
Targeted Allele Detail

Summary

• Symbol: Ccar2^tm1Dac
• Name: cell cycle activator and apoptosis regulator 2; targeted mutation 1, Domenico Accili
• MGI ID: MGI:5776716
• Synonyms: Dbc1^-
• Gene: Ccar2 Location: Chr14:70375613-70391260 bp, - strand Genetic Position: Chr14, 36.24 cM
• Alliance: Ccar2^tm1Dac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228688
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The EGFP-neomycin resistance gene cassette replaced the 3' portion of exon 2. Western blot confirmed the absence of protein expression. (J:228688)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccar2 Mutation: 37 strains or lines available

References

• Original: J:228688 Qiang L, et al., Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. Cell Rep. 2015 Jun 23;11(11):1797-808
• All: 1 reference(s)