Sf3b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sf3b1
splicing factor 3b, subunit 1
MGI:1932339

24 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sf3b1^tm1.1Mdf/Sf3b1⁺ Tg(Mx1-cre)1Cgn/? involves: 129S4/SvJae * C57BL/6 * CBA/J	abnormal erythroid progenitor cell morphology	J:234976
	abnormal erythropoiesis	J:234976
	abnormal myelopoiesis	J:234976
	decreased erythrocyte cell number	J:234976
	decreased granulocyte monocyte progenitor cell number	J:234976
	hypochromic macrocytic anemia	J:234976
	impaired hematopoiesis	J:234976
	increased circulating erythropoietin level	J:234976
	increased hematopoietic stem cell number	J:234976
	increased mean corpuscular volume	J:234976
	macrocytosis	J:234976
	premature death	J:234976
Sf3b1^tm1Hko/Sf3b1⁺ B6.Cg-Sf3b1^tm1Hko	cervical vertebral transformation	J:96358
	lumbar vertebral transformation	J:96358
	thoracic vertebral transformation	J:96358
Sf3b1^tm1Hko/Sf3b1⁺ Not Specified	abnormal bone marrow cell morphology/development	J:324276
	decreased erythrocyte cell number	J:324276
	decreased hemoglobin content	J:324276
	extramedullary hematopoiesis	J:324276
	hypoactivity	J:324276
	increased mean corpuscular volume	J:324276
	increased spleen red pulp amount	J:324276
	macrocytic anemia	J:324276
	reduced fertility	J:324276
	thrombocytosis	J:324276
Sf3b1^tm1Hko/Sf3b1^tm1Hko B6.Cg-Sf3b1^tm1Hko	embryonic lethality before implantation, complete penetrance	J:96358

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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