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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
MGI:1930134
26 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Ern1tm1Dron/Ern1+
129S.129S6-Ern1tm1Dron
abnormal glucose homeostasis J:132805
abnormal response/metabolism to endogenous compounds J:132805
Ern1tm1Dron/Ern1tm1Dron
involves: 129S6/SvEvTac
embryonic lethality during organogenesis, complete penetrance J:132966
Ern1tm1Rjk/Ern1tm1Rjk
involves: 129S1/Sv * 129X1/SvJ
abnormal cell physiology J:124971
Ern1tm1Rjk/Ern1tm1Rjk
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal definitive hematopoiesis J:106975
abnormal pro-B cell morphology J:106975
decreased embryo size J:106975
embryonic growth retardation J:106975
embryonic lethality during organogenesis, complete penetrance J:106975
liver hypoplasia J:106975
pallor J:106975
Ern1tm1Rjk/Ern1tm2.1Rjk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
abnormal apolipoprotein level J:171230
abnormal hepatocyte morphology J:171230
abnormal lipid level J:171230
decreased circulating cholesterol level J:171230
hepatic steatosis J:171230
increased hepatocyte apoptosis J:171230
increased liver triglyceride level J:171230
Ern1tm1Tiw/Ern1tm1Tiw
involves: 129S4/SvJae * C57BL/6
abnormal extraembryonic tissue physiology J:153222
abnormal placenta labyrinth morphology J:153222
abnormal placental labyrinth vasculature morphology J:153222
abnormal placental transport J:153222
abnormal trophoblast layer morphology J:153222
decreased embryo size J:153222
embryonic lethality during organogenesis, complete penetrance J:153222
small placenta J:153222
Ern1tm2.1Rjk/Ern1tm2.1Rjk
Not Specified
no abnormal phenotype detected J:171230
Ern1tm2.1Tiw/Ern1tm2.2Tiw
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJae * C57BL/6
normal embryo phenotype J:153222
normal liver/biliary system phenotype J:153222

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory