Ern1em1Yarg
Endonuclease-mediated Allele Detail
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| Symbol: |
Ern1em1Yarg |
| Name: |
endoplasmic reticulum to nucleus signalling 1; endonuclease-mediated mutation 1, Yair Argon |
| MGI ID: |
MGI:8319099 |
| Synonyms: |
IRE1C148S |
| Gene: |
Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
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| Alliance: |
Ern1em1Yarg page
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| Strain of Origin: |
Not Applicable
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| Allele Type: |
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Endonuclease-mediated (Not Applicable) |
| Mutation: |
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Nucleotide substitutions
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Mutation details: Cysteine codon 150 (TGC) was changed to serine (AGT) (p.C150S) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation enhances the encoded protein's activity and leads to improved clinical outcomes after experimental autoimmune encephalomyelitis (EAE).
(J:355491)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ern1 Mutation: |
58 strains or lines available
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| Original: |
J:355491 Bracchi-Ricard V, et al., Increased activity of IRE1 improves the clinical presentation of EAE. FASEB J. 2023 Dec;37(12):e23283 |
| All: |
1 reference(s) |
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Analysis Tools
