Phenotypes associated with this allele

• Allele Symbol: Ern1^em1Yarg
• Allele Name: endonuclease-mediated mutation 1, Yair Argon
• Allele ID: MGI:8319099
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ern1^em1Yarg/Ern1^em1Yarg	Not Specified	MGI:8319103

Genotype
MGI:8319103

hm1

• Allelic Composition: Ern1^em1Yarg/Ern1^em1Yarg
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:355491 )

N • normal pain sensitivity and response

immune system

immune system phenotype ( J:355491 )

N • normal development and responses

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:355491 )

• delayed day of onset

• shorter period of clinical score equal to or greater than 2

• improved clinical outcome at end of experiment compared to peak

• reduced weight loss during acute phase

• no demyelination in spinal cord

• reduced spinal cord axon degeneration

• normal day of peak disease and maximum clinical score at peak

nervous system

nervous system phenotype ( J:355491 )

N • normal brain white and gray matter

N • normal spinal cord morphology

N • normal numbers of oligodendrocyte precursor cells (OPCs) and oligodendrocytes in spinal cord