86 phenotypes from 9 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hprt1tm1(ACTB-Opa1)Lsc/Y involves: 129 * C57BL/6 * C57BL/6J	abnormal mitochondrial crista morphology	J:214492
	abnormal mitochondrial physiology	J:214492
	decreased susceptibility to injury	J:214492
	normal growth/size/body region phenotype	J:214492
Opa1em1(IMPC)Bay/Opa1em1(IMPC)Bay C57BL/6N-Opa1em1(IMPC)Bay/BayMmucd	abnormal embryo size	J:211773
	abnormal embryo turning	J:211773
	abnormal forebrain development	J:211773
	abnormal heart morphology	J:211773
	abnormal neural tube closure	J:211773
	abnormal neural tube morphology	J:211773
	abnormal pharyngeal arch morphology	J:211773
	abnormal somite shape	J:211773
	abnormal visceral yolk sac morphology	J:211773
	embryonic growth retardation	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Opa1lilr3/Opa1lilr3 involves: C3H/HeJ * C57BL/6J	abnormal craniofacial morphology	J:162916
	abnormal frontonasal prominence morphology	J:162916
	abnormal mitochondrial morphology	J:162916
	abnormal pharyngeal arch morphology	J:162916
	abnormal rostral-caudal axis patterning	J:162916
	abnormal somite shape	J:162916
	decreased embryo size	J:162916
	decreased somite size	J:162916
	embryonic growth retardation	J:162916
	embryonic lethality during organogenesis, complete penetrance	J:162916
	exencephaly	J:162916
	hemorrhage	J:162916
	incomplete embryo turning	J:162916
Opa1lilr3/Opa1lilr3 involves: C3HeB/FeJ * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:98216
	exencephaly	J:98216
Opa1M1Bewi/Opa1+ involves: C3HeB/FeJ	decreased susceptibility to age related obesity	J:154865
	decreased total body fat amount	J:154865
	impaired coordination	J:154865
	limb grasping	J:154865
	normal muscle phenotype	J:154865
	tremors	J:154865
Opa1M1Bewi/Opa1+ involves: C3HeB/FeJ * C57BL/6	abnormal optic disk morphology	J:154966
	abnormal optic nerve morphology	J:154966
	abnormal retina nerve fiber layer morphology	J:154966
	decreased retina ganglion cell number	J:154966
	gliosis	J:154966
	normal hearing/vestibular/ear phenotype	J:154966
	thin retina inner plexiform layer	J:154966
Opa1M1Bewi/Opa1M1Bewi involves: C3HeB/FeJ * C57BL/6	edema	J:154966
	embryonic growth retardation	J:154966
	embryonic lethality, complete penetrance	J:154966
Opa1Q285X/Opa1+ involves: C3HeB/FeJ * C57BL/6JCrl	abnormal eye electrophysiology	J:189276
	abnormal forebrain development	J:121779
	abnormal mitochondrial morphology	J:121779
	abnormal optic nerve morphology	J:121779
	abnormal response to new environment	J:121779
	abnormal vision	J:121779
	abnormal visual evoked potential	J:189276
	embryonic growth retardation	J:121779
	normal reproductive system phenotype	J:121779
Opa1Q285X/Opa1Q285X involves: C3HeB/FeJ * C57BL/6JCrl	abnormal embryo development	J:121779
	abnormal embryo turning	J:121779
	abnormal forebrain development	J:121779
	decreased embryo size	J:121779
	embryonic growth retardation	J:121779
	embryonic lethality during organogenesis, complete penetrance	J:121779
Opa1tm1.1Geno/Opa1+ involves: 129S2/SvPas	abnormal autophagy	J:237963
	abnormal cardiac muscle tissue morphology	J:237963
	abnormal cerebellum morphology	J:237963
	abnormal enzyme/coenzyme activity	J:237963
	abnormal lateral ventricle morphology	J:237963
	abnormal mitochondrial morphology	J:237963
	abnormal mitochondrial physiology	J:237963
	abnormal mitochondrial shape	J:237963
	abnormal mitophagy	J:237963
	abnormal muscle fiber morphology	J:237963
	abnormal optic nerve morphology	J:237963
	abnormal retina ganglion cell morphology	J:237963
	abnormal sarcomere morphology	J:237963
	abnormal sciatic nerve morphology	J:237963
	abnormal vision	J:237963
	abnormal visual evoked potential	J:237963
	ataxia	J:237963
	axon degeneration	J:237963
	cerebellum atrophy	J:237963
	deafness	J:237963
	decreased heart weight	J:237963
	decreased mitochondrial number	J:237963
	decreased muscle fiber mitochondrial DNA content	J:237963
	demyelination	J:237963
	dilated fourth ventricle	J:237963
	dilated lateral ventricle	J:237963
	disorganized mitochondrial cristae	J:237963
	impaired coordination	J:237963
	increased creatine level	J:237963
	increased mitochondrial number	J:237963
	increased mitochondrial size	J:237963
	increased or absent threshold for auditory brainstem response	J:237963
	retina ganglion cell degeneration	J:237963
Opa1tm1.1Geno/Opa1tm1.1Geno involves: 129S2/SvPas	embryonic lethality, complete penetrance	J:237963
Opa1tm1.1Hise/Opa1tm1.2Hise Tg(Ins2-cre)25Mgn/0 involves: 129S/SvEv * C57BL/6 * DBA * SJL	abnormal mitochondrial crista morphology	J:183074
	abnormal mitochondrial morphology	J:183074
	abnormal pancreatic beta cell morphology	J:183074
	abnormal pancreatic beta cell physiology	J:183074
	abnormal respiratory electron transport chain	J:183074
	decreased circulating insulin level	J:183074
	decreased insulin secretion	J:183074
	decreased oxygen consumption	J:183074
	decreased pancreatic beta cell number	J:183074
	decreased pancreatic beta cell proliferation	J:183074
	normal homeostasis/metabolism phenotype	J:183074
	impaired glucose tolerance	J:183074
	increased circulating glucose level	J:183074
	small pancreatic islets	J:183074
Opa1tm1.2Hise/Opa1tm1.2Hise involves: 129S/SvEv * C57BL/6 * FVB/N	embryonic lethality, complete penetrance	J:183074
Opa1tm1Lsc/Opa1tm1Lsc involves: C57BL/6J	abnormal mitochondrial crista morphology	J:214492
	abnormal mitochondrial physiology	J:214492