Opa1^tm1.2Hise
Targeted Allele Detail

Summary

• Symbol: Opa1^tm1.2Hise
• Name: OPA1, mitochondrial dynamin like GTPase; targeted mutation 1.2, Hiromi Sesaki
• MGI ID: MGI:5317789
• Gene: Opa1 Location: Chr16:29398152-29473702 bp, + strand Genetic Position: Chr16, 20.65 cM, cytoband B2
• Alliance: Opa1^tm1.2Hise page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183074
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv and C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 10 through 13 and the neo cassette. This deletion removes an essential GTPase domain. (J:183074)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opa1 Mutation: 54 strains or lines available

References

• Original: J:183074 Zhang Z, et al., The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011 Jul 1;22(13):2235-45
• All: 2 reference(s)