Ddah1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ddah1
dimethylarginine dimethylaminohydrolase 1
MGI:1916469

24 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ddah1^tm1.1Geno/Ddah1^tm1.1Geno Not Specified	abnormal amino acid level	J:234529
Ddah1^tm1.1Geno/Ddah1^tm1.1Geno Not Specified	abnormal circulating amino acid level	J:234529
Ddah1^tm1.1Yjch/Ddah1^tm1.1Yjch involves: 129S1/Sv * 129S4/SvJae	abnormal amino acid level	J:182373
	abnormal circulating amino acid level	J:182373
	abnormal enzyme/coenzyme activity	J:182373
	abnormal nitric oxide homeostasis	J:182373
	normal cardiovascular system phenotype	J:182373
	increased systemic arterial blood pressure	J:182373
Ddah1^tm1Geno/Ddah1^tm1Geno Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * SJL	abnormal physiological neovascularization	J:234529
	normal cardiovascular system phenotype	J:234529
	decreased angiogenesis	J:234529
	normal homeostasis/metabolism phenotype	J:234529
Ddah1^tm1Pval/Ddah1⁺ involves: 129X1/SvJ * C57BL/6	abnormal cardiovascular system physiology	J:121719
	abnormal circulating amino acid level	J:121719
	abnormal nitric oxide homeostasis	J:121719
	abnormal pulmonary artery morphology	J:121719
	abnormal vasodilation	J:121719
	decreased cardiac output	J:121719
	decreased heart rate	J:121719
	increased mean systemic arterial blood pressure	J:121719
	increased vasoconstriction	J:121719
Ddah1^tm1Pval/Ddah1^tm1Pval involves: 129X1/SvJ	embryonic lethality before implantation, incomplete penetrance	J:155618
Ddah1^tm1Pval/Ddah1^tm1Pval involves: 129X1/SvJ * C57BL/6	prenatal lethality, complete penetrance	J:121719
Ddah1^tm1Yjch/Ddah1^tm1Yjch Tg(Tek-cre)12Flv/0 involves: 129S1/Sv * C57BL/6J	abnormal amino acid level	J:168130
	abnormal circulating amino acid level	J:168130
	abnormal nitric oxide homeostasis	J:168130
	abnormal vascular smooth muscle physiology	J:168130
	normal cardiovascular system phenotype	J:168130
	increased left ventricle systolic pressure	J:168130
	increased mean systemic arterial blood pressure	J:168130
	increased systemic arterial blood pressure	J:168130
	increased systemic arterial systolic blood pressure	J:168130
	increased systemic vascular resistance	J:168130
Ddah1^{tm2a(EUCOMM)Wtsi}/Ddah1^{tm2a(EUCOMM)Wtsi} C57BL/6N-Ddah1^{tm2a(EUCOMM)Wtsi}/Wtsi	decreased erythrocyte cell number	J:211773
	increased grip strength	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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