Foxo3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Foxo3
forkhead box O3
MGI:1890081

29 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Foxo3^tm1Rdp/Foxo3^tm1.1Rdp Amhr2^tm3(cre)Bhr/Amhr2⁺ involves: 129S6/SvEvTac * 129S7/SvEvBrd	abnormal circulating hormone level	J:232961
	abnormal ovarian follicle morphology	J:232961
	decreased circulating luteinizing hormone level	J:232961
	increased circulating estradiol level	J:232961
	increased granulosa cell tumor incidence	J:232961
	ovary cyst	J:232961
	suppressed circulating follicle stimulating hormone level	J:232961
Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Foxo3^tm1Rdp/Foxo3^tm1.1Rdp Pten^tm1Hwu/Pten^tm1Hwu Tg(CYP19A1-cre)1Jri/0 involves: 129S4/SvJae * 129S6/SvEvTac	abnormal circulating hormone level	J:232961
	decreased circulating luteinizing hormone level	J:232961
	increased granulosa cell tumor incidence	J:232961
	suppressed circulating follicle stimulating hormone level	J:232961
Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Foxo3^tm1Rdp/Foxo3^tm1.1Rdp Tg(CYP19A1-cre)1Jri/0 involves: 129S6/SvEvTac	abnormal circulating hormone level	J:232961
	abnormal granulosa cell morphology	J:232961
	abnormal ovarian follicle morphology	J:232961
	decreased circulating luteinizing hormone level	J:232961
	increased circulating estradiol level	J:232961
	increased granulosa cell tumor incidence	J:232961
	suppressed circulating follicle stimulating hormone level	J:232961
Foxo1^tm1Rdp/Foxo1^tm1Rdp Foxo3^tm1Rdp/Foxo3^tm1Rdp Foxo4^tm1Rdp/Foxo4^tm1Rdp Tg(Ins2-cre)23Herr/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA/J	abnormal glucose homeostasis	J:215526
	abnormal mitochondrial physiology	J:215526
	abnormal pancreatic beta cell differentiation	J:215526
	abnormal pancreatic beta cell physiology	J:215526
	decreased circulating insulin level	J:215526
	decreased insulin secretion	J:215526
	hyperglycemia	J:215526
	impaired glucose tolerance	J:215526
Foxo1^tm1Rdp/Foxo1^tm1Rdp Foxo3^tm1Rdp/Foxo3^tm1Rdp Foxo4^tm1Rdp/Foxo4^tm1Rdp Tg(Mx1-cre)1Cgn/0 involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N	increased hamartoma incidence	J:118179
	increased hemangioma incidence	J:118179
	increased hemangiosarcoma incidence	J:118179
	increased T cell derived lymphoma incidence	J:118179
	premature death	J:118179
Foxo1^tm1Rdp/Foxo1^tm1Rdp Foxo3^tm1Rdp/Foxo3^tm1Rdp Tg(Mx1-cre)1Cgn/0 involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N	abnormal blood vessel morphology	J:118179
	increased hemangioma incidence	J:118179
	increased hemangiosarcoma incidence	J:118179
	increased hepatic hemangioma incidence	J:118179
	increased tumor incidence	J:118179
	premature death	J:118179
Foxo3^tm1.1Rdp/Foxo3⁺ Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp involves: 129S1/Sv * 129S6/SvEvTac * FVB/N	increased Harderian gland tumor incidence	J:118179
	increased ovary tumor incidence	J:118179
	increased pituitary adenoma incidence	J:118179
	increased tumor incidence	J:118179
Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp Foxo4^tm1.1Rdp/Foxo4^tm1.1Rdp involves: 129S1/Sv * 129S6/SvEvTac * FVB/N	increased Harderian gland tumor incidence	J:118179
	increased lung adenoma incidence	J:118179
	increased ovarian teratoma incidence	J:118179
	increased ovary tumor incidence	J:118179
	increased pituitary adenoma incidence	J:118179
	increased tumor incidence	J:118179

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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