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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Prkn
parkin RBR E3 ubiquitin protein ligase
MGI:1355296
49 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Prkntm1.1Muqit/Prkntm1.1Muqit
C57BL/6-Prkntm1.1Muqit
no abnormal phenotype detected J:101977
Prkntm1Ccs/Prkntm1Ccs
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal dopamine level J:127250
abnormal neuron morphology J:127707
abnormal spatial learning J:127250
normal behavior/neurological phenotype J:127250
brain vacuoles J:127707
decreased exploration in new environment J:127250
impaired behavioral response to xenobiotic J:127250
increased anxiety-related response J:127250
increased thigmotaxis J:127250
normal nervous system phenotype J:127250, J:127707
Prkntm1Ccs/Prkntm1Ccs
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal CNS glial cell morphology J:168847
abnormal mitochondrion morphology J:168847
Prkntm1Roo/Prkntm1Roo
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
abnormal stationary movement J:85561
abnormal synaptic transmission J:85561
decreased body weight J:85561
decreased core body temperature J:85561
decreased exploration in new environment J:85561
increased dopamine level J:85561
normal muscle phenotype J:85561
normal nervous system phenotype J:85561
Prkntm1Roo/Prkntm1Roo
involves: 129S2/SvPas
abnormal locomotor activation J:125148
abnormal posture J:125148
abnormal respiratory function J:125148
abnormal tail movements J:125148
alopecia J:125148
decreased substantia nigra size J:125148
hippocampal neuron degeneration J:125148
increased neuron apoptosis J:125148
kyphosis J:125148
loss of dopaminergic neurons J:125148
neuron degeneration J:125148
premature death J:125148
short stride length J:125148
tau protein deposits J:125148
Prkntm1Rpa/Prkntm1Rpa
involves: 129S4/SvJaeSor * C57BL/6
normal behavior/neurological phenotype J:95204
normal homeostasis/metabolism phenotype J:95204
normal nervous system phenotype J:95204
Prkntm1Shn/Prkntm1Shn
B6.129S4-Prkntm1Shn/J
abnormal autophagy J:193741
abnormal mitochondrial physiology J:193741
abnormal mitochondrion morphology J:193741
abnormal mitophagy J:193741
altered response to myocardial infarction J:193741
decreased body size J:193741
decreased mitochondria size J:193741
impaired coordination J:202221
increased sensitivity to induced cell death J:193741, J:194987
increased sensitivity to induced morbidity/mortality J:193741
Prkntm1Shn/Prkntm1Shn
involves: 129S4/SvJae
abnormal nervous system electrophysiology J:86377
impaired coordination J:86377
increased dopamine level J:86377
Prkntm1Tmd/Prkntm1Tmd
involves: C57BL/6
abnormal locus ceruleus morphology J:91487
decreased noradrenaline level J:91487
decreased startle reflex J:91487
Prkntm1Ykt/Prkntm1Ykt
involves: 129P2/OlaHsd * C57BL/6
abnormal substantia nigra pars compacta morphology J:117737
decreased body weight J:117737
increased dopamine level J:117737
Prkntm2Tmd/Prkntm2Tmd
Not Specified
decreased dopaminergic neuron number J:171058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory