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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nbn
nibrin
MGI:1351625
28 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atmtm1Awb/Atmtm1Awb
Nbntm1Jpt/Nbntm1Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		embryonic lethality, complete penetrance J:75956
Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt
involves: 129S6/SvEvTac * 129/Sv 		decreased cellular sensitivity to ionizing radiation J:129762
Lig4tm1Icrf/Lig4tm1Icrf
Nbntm1Jpt/Nbntm1Jpt
involves: 129 * 129S7/SvEvBrd 		normal cellular phenotype J:144172
prenatal lethality, complete penetrance J:144172
Lig4tm1Icrf/Lig4tm1Icrf
Nbntm2.1Jpt/Nbntm2.1Jpt
involves: 129 		perinatal lethality, complete penetrance J:144172
Lig4tm1Pmc/Lig4tm1Pmc
Nbntm1Jpt/Nbntm1Jpt
Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal brain development J:144172
decreased brain weight J:144172
microcephaly J:144172
Nbnem3Jpt/Nbnem3Jpt
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas 		decreased tumor latency J:251434
increased hemangiosarcoma incidence J:251434
increased histiocytic sarcoma incidence J:251434
increased leiomyosarcoma incidence J:251434
increased rhabdomyosarcoma incidence J:251434
increased squamous cell carcinoma incidence J:251434
Nbnem4Jpt/Nbnem4Jpt
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas 		decreased tumor latency J:251434
increased hemangiosarcoma incidence J:251434
increased histiocytic sarcoma incidence J:251434
increased leiomyosarcoma incidence J:251434
increased rhabdomyosarcoma incidence J:251434
increased squamous cell carcinoma incidence J:251434
Nbntm1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		normal hematopoietic system phenotype J:103922
Nbntm1Jpt/Nbntm1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		normal hematopoietic system phenotype J:103922
Nbntm1Jpt/Nbntm1Jpt
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S7/SvEvBrd 		decreased tumor latency J:75956
increased lymphoma incidence J:75956
increased teratoma incidence J:75956
premature death J:75956
Nbntm2.1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * 129/Sv 		anemia J:129762
decreased apoptosis J:129762
normal mortality/aging J:129762
Nbntm2.1Jpt/Nbntm2.1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * 129/Sv 		anemia J:129762
decreased apoptosis J:129762
normal mortality/aging J:129762
Nbntm2Zqw/Nbntm2Zqw
Trp53tm1Brd/Trp53+
Tg(Nes-cre)1Wme/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal cerebellar foliation J:98316
abnormal cerebellar granule layer morphology J:98316
impaired balance J:98316
Nbntm2Zqw/Nbntm2Zqw
Trp53tm1Brd/Trp53tm1Brd
Tg(Nes-cre)1Wme/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA 		normal behavior/neurological phenotype J:98316
increased lymphoma incidence J:98316
increased sarcoma incidence J:98316
increased tumor incidence J:98316
normal nervous system phenotype J:98316
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory