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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Casr
calcium-sensing receptor
MGI:1351351
64 phenotypes from 10 alleles in 15 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
CasrBCH002/CasrBCH002
C3HeB/FeJ-CasrBCH002 		abnormal coat/hair pigmentation J:183993
decreased body size J:183993
decreased circulating phosphate level J:183993
increased circulating calcium level J:183993
CasrBCH003/CasrBCH003
C3HeB/FeJ-CasrBCH003 		increased circulating calcium level J:183993
CasrBCH004/CasrBCH004
C3HeB/FeJ-CasrBCH004 		increased circulating calcium level J:183993
CasrBCH007/CasrBCH007
C3HeB/FeJ-CasrBCH007 		decreased body size J:183993
increased circulating calcium level J:183993
CasrBCH011/CasrBCH011
C3HeB/FeJ-CasrBCH011 		increased circulating calcium level J:183993
CasrBCH013/CasrBCH013
C3HeB/FeJ-CasrBCH013 		increased circulating calcium level J:183993
CasrNuf/Casr+
either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH) 		cataract J:92612
decreased circulating calcium level J:92612
decreased circulating parathyroid hormone level J:92612
increased circulating phosphate level J:92612
CasrNuf/CasrNuf
involves: 102/El * C3H/He 		calcified muscle J:92612
calcinosis J:92612
cataract J:92612
decreased circulating calcium level J:92612
decreased circulating parathyroid hormone level J:92612
decreased urine calcium level J:92612
decreased urine phosphate level J:92612
increased circulating phosphate level J:92612
nephrocalcinosis J:92612
premature death J:92612
tongue inflammation J:92612
Casrtm1b(KOMP)Mbp/Casr+
C57BL/6N-Casrtm1b(KOMP)Mbp/Tcp 		abnormal pancreas morphology J:211773
decreased prepulse inhibition J:211773
edema J:211773
enlarged uterus J:211773
increased circulating calcium level J:211773
increased circulating phosphate level J:211773
small superior vagus ganglion J:211773
Casrtm1b(KOMP)Mbp/Casrtm1b(KOMP)Mbp
C57BL/6N-Casrtm1b(KOMP)Mbp/Tcp 		preweaning lethality, complete penetrance J:211773
Casrtm1Ces/Casr+
involves: 129X1/SvJ * Black Swiss 		decreased urine calcium level J:29900
normal endocrine/exocrine gland phenotype J:29900
normal growth/size/body region phenotype J:29900
normal hematopoietic system phenotype J:29900
increased circulating calcium level J:29900
increased circulating magnesium level J:29900
increased circulating parathyroid hormone level J:29900
normal renal/urinary system phenotype J:29900
normal skeleton phenotype J:29900
Casrtm1Ces/Casrtm1Ces
involves: 129X1/SvJ * Black Swiss 		abnormal bone mineralization J:71056
abnormal parathyroid gland chief cell morphology J:29900
abnormal postural reflex J:29900
abnormal posture J:29900
aphagia J:29900
decreased body size J:71056
decreased body weight J:71056
decreased bone mineral density J:29900
decreased circulating phosphate level J:71056
decreased urine calcium level J:29900
dehydration J:29900
delayed bone ossification J:71056
enlarged parathyroid gland J:29900
increased circulating calcium level J:29900
increased circulating magnesium level J:29900
increased circulating parathyroid hormone level J:29900
increased hematocrit J:29900
increased width of hypertrophic chondrocyte zone J:71056
kyphoscoliosis J:29900
lethargy J:29900
parathyroid gland hyperplasia J:29900
pigmented parathyroid gland J:29900
postnatal growth retardation J:29900
postnatal lethality, complete penetrance J:29900, J:71056
rickets J:71056
Casrtm1Wch/Casr+
Tg(PTH-cre)4167Slib/0
involves: 129S4/SvJae * C57BL/6 * FVB 		decreased bone mineral density J:180651
decreased bone trabecula number J:180651
decreased compact bone thickness J:180651
decreased compact bone volume J:180651
decreased trabecular bone thickness J:180651
increased circulating calcium level J:180651
increased circulating parathyroid hormone level J:180651
increased urine calcium level J:180651
normal skeleton phenotype J:180651
Casrtm1Wch/Casrtm1Wch
Tg(Col1a1-cre)2Bek/0
involves: 129S4/SvJae * C57BL/6 * CD-1 		abnormal skeleton development J:180651
abnormal skeleton morphology J:180651
abnormal trabecular bone morphology J:180651
decreased body size J:180651
decreased body weight J:180651
decreased bone mineral density J:180651
decreased bone mineralization J:180651
decreased bone trabecula number J:180651
decreased compact bone thickness J:180651
decreased compact bone volume J:180651
decreased trabecular bone connectivity density J:180651
decreased trabecular bone thickness J:180651
decreased trabecular bone volume J:180651
fragile skeleton J:180651
postnatal growth retardation J:180651
postnatal lethality, complete penetrance J:180651
Casrtm1Wch/Casrtm1Wch
Tg(Col2a1-cre)1Bhr/0
involves: 129S4/SvJae * C57BL/6 * SJL 		abnormal skeleton development J:180651
decreased bone mineralization J:180651
embryonic lethality during organogenesis, incomplete penetrance J:180651
lethality throughout fetal growth and development, complete penetrance J:180651
Casrtm1Wch/Casrtm1Wch
Tg(Col2a1-cre/ERT)KA3Smac/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal skeleton development J:180651
decreased bone mineralization J:180651
increased width of hypertrophic chondrocyte zone J:180651
Casrtm1Wch/Casrtm1Wch
Tg(PTH-cre)4167Slib/0
involves: 129S4/SvJae * C57BL/6 * FVB 		abnormal skeleton development J:180651
abnormal skeleton morphology J:180651
decreased body weight J:180651
decreased bone mineral content J:180651
decreased bone mineral density J:180651
decreased bone mineralization J:180651
fragile skeleton J:180651
increased circulating calcium level J:180651
increased circulating parathyroid hormone level J:180651
increased urine calcium level J:180651
postnatal growth retardation J:180651
postnatal lethality, complete penetrance J:180651
Casrtm1Wch/Casrtm1Wch
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S4/SvJae * C57BL/6 * CD-1 		abnormal skeleton development J:180651
abnormal trabecular bone morphology J:180651
decreased body size J:180651
decreased bone mineralization J:180651
decreased bone trabecula number J:180651
decreased compact bone volume J:180651
decreased trabecular bone connectivity density J:180651
decreased trabecular bone thickness J:180651
decreased trabecular bone volume J:180651
postnatal growth retardation J:180651
normal skeleton phenotype J:180651
Casrtm1Wch/Casrtm1Wch
Tg(Vil1-cre)997Gum/0
involves: 129S4/SvJae * C57BL/6J * SJL 		abnormal enterocyte proliferation J:179672
abnormal large intestine crypts of Lieberkuhn morphology J:179672
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory