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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spo11
SPO11 initiator of meiotic double stranded breaks
MGI:1349669
15 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fignl1tm1Osb/Fignl1tm1.1Osb
Spo11tm1Mjn/Spo11tm1Mjn
Tg(Stra8-cre)1Osb/0
involves: 129X1/SvJ * C57BL/6 		arrest of male meiosis J:342157
Hormad1tm1.2Atot/Hormad1tm1.2Atot
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129/Sv * BALB/c * C57BL/6 * SJL 		abnormal female meiosis J:173089
abnormal male meiosis J:173089, J:292036
abnormal synaptonemal complex J:173089
normal reproductive system phenotype J:173089
Hormad1tm1Atot/Hormad1tm1Atot
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd 		abnormal female meiosis J:173089
abnormal male meiosis J:173089
abnormal synaptonemal complex J:173089
normal reproductive system phenotype J:173089
Hormad1tm1Kura/Hormad1tm1Kura
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal female meiosis J:213984
abnormal male germ cell apoptosis J:213984
abnormal male meiosis J:213984
normal reproductive system phenotype J:213984
Hormad2tm1.2Atot/Hormad2tm1.2Atot
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL 		abnormal meiosis J:183982
normal reproductive system phenotype J:183982
Hormad2tm1Atot/Hormad2tm1Atot
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd 		abnormal meiosis J:183982
normal reproductive system phenotype J:183982
Hormad2tm1Kura/Hormad2+
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal female meiosis J:192634
decreased oocyte number J:192634
normal reproductive system phenotype J:192634
Hormad2tm1Kura/Hormad2tm1Kura
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal female meiosis J:192634
abnormal testis morphology J:192634
normal reproductive system phenotype J:192634
Maeltm1Bort/Maeltm1Bort
Spo11tm1Rdco/Spo11tm1Rdco
involves: 129 * C57BL/6 		abnormal male meiosis J:140402
Mcmdc2tm3b(EUCOMM)Hmgu/Mcmdc2tm3b(EUCOMM)Hmgu
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6N * CD-1 		abnormal double-strand DNA break repair J:236226
abnormal synaptonemal complex J:236226
Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6N 		absent oocytes J:231231
arrest of male meiosis J:231231
azoospermia J:231231
Psmc3iptm1Rdco/Psmc3iptm1Rdco
Spo11tm1.1Gvpc/Spo11tm1.1Gvpc
involves: 129S6/SvEvTac * C57BL/6 		abnormal double-strand DNA break repair J:202231
Rad21ltm1Yow/Rad21ltm1Yow
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal chromosomal synapsis J:209347
abnormal male meiosis J:209347
abnormal synaptonemal complex J:209347
Rad50tm4.1Jpt/Rad50+
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129/Sv * C57BL/6 		abnormal seminiferous tubule morphology J:209141
Rec8mei8/Rec8mei8
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J 		abnormal male meiosis J:209347
abnormal synaptonemal complex J:209347
Spo11tm1Mjn/Spo11+
Stag3tm1e.1(KOMP)Wtsi/Stag3tm1e.1(KOMP)Wtsi
B6.Cg-Spo11tm1Mjn Stag3tm1e.1(KOMP)Wtsi/2J 		abnormal double-strand DNA break repair J:280261
Spo11tm1Mjn/Spo11tm1Mjn
Syce2Gt(FHCRC-GT-S8-7E1)Sor/Syce2Gt(FHCRC-GT-S8-7E1)Sor
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6JOlaHsd 		arrest of spermatogenesis J:173089
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory