Syce2^{Gt(FHCRC-GT-S8-7E1)Sor}
Gene trapped Allele Detail

Summary

• Symbol: Syce2^{Gt(FHCRC-GT-S8-7E1)Sor}
• Name: synaptonemal complex central element protein 2; gene trap FHCRC-GT-S8-7E1, Philippe Soriano
• MGI ID: MGI:3708176
• Synonyms: Syce^gtr1
• Gene: Syce2 Location: Chr8:85598740-85614075 bp, + strand Genetic Position: Chr8, 41.25 cM
• Alliance: Syce2^{Gt(FHCRC-GT-S8-7E1)Sor} page

Mutation origin

• Mutant Cell Line: S8-7E1
• Germline Transmission: Earliest citation of germline transmission: J:119809
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSAFARY
• Mutation details: The gene trap vector ROSAFARY is inserted into exon 2 creating a null allele. No protein was detected in testis cell spreads. (J:119809)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-S8-7E1	CG691689 ; (MGI Seq Detail)	3' RACE	Chr8:85599361-85614024 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  5 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Syce2 Mutation: 16 strains or lines available

References

• Original: J:119809 Bolcun-Filas E, et al., SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination. J Cell Biol. 2007 Mar 12;176(6):741-7
• All: 5 reference(s)