Syce2 MGI Mouse Gene Detail - MGI:1919096 - synaptonemal complex central element protein 2

Symbol

Syce2
Name

synaptonemal complex central element protein 2
Synonyms

1700013H19Rik

Feature Type

protein coding gene
IDs

MGI:1919096
NCBI Gene: 71846
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:85598740-85614075 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 41.25 cM
Mapping Data

2 experiments

SNPs within 2kb

365 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919096	protein coding gene	Chr8:85598740-85614850 (+)
129S1/SvImJ	ENSMUSG00200024004	protein coding gene	Chr8:79963773-79980113 (+)
A/J	ENSMUSG00195014536	protein coding gene	Chr8:80321963-80338314 (+)
AKR/J	ENSMUSG00220021897	protein coding gene	Chr8:80363350-80379690 (+)
BALB/cJ	ENSMUSG00180019308	protein coding gene	Chr8:80162456-80178800 (+)
C3H/HeJ	ENSMUSG00175010764	protein coding gene	Chr8:80257645-80273997 (+)
C57BL/6NJ	ENSMUSG00215008956	protein coding gene	Chr8:79895031-79911141 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031313	protein coding gene	Chr8:76211524-76227848 (+)
CAST/EiJ	ENSTCUG00005033671	protein coding gene	Chr8:79772092-79788464 (+)
CBA/J	ENSMUSG00210020059	protein coding gene	Chr8:80244773-80261126 (+)
DBA/2J	ENSMUSG00185036731	protein coding gene	Chr8:86353380-86369732 (+)
FVB/NJ	ENSMUSG00205021887	protein coding gene	Chr8:79300593-79316947 (+)
JF1/MsJ	ENSUMUG00000015891	protein coding gene	Chr8:88661537-88677667 (+)
LP/J	ENSMUSG00230028864	protein coding gene	Chr8:89960624-89979190 (+)
NOD/ShiLtJ	ENSMUSG00190026626	protein coding gene	Chr8:80321122-80337487 (+)
NZO/HlLtJ	ENSMUSG00225038997	protein coding gene	Chr8:93355747-93371857 (+)
PWK/PhJ	ENSLUMG00010027634	protein coding gene	Chr8:79999010-80015131 (+)
SPRET/EiJ	ENSMSPG00010024465	protein coding gene	Chr8:81911439-81928126 (+)
WSB/EiJ	ENSIUOG00005015667	protein coding gene	Chr8:81058693-81075032 (+)

Human Ortholog

SYCE2, synaptonemal complex central element protein 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYCE2, synaptonemal complex central element protein 2
Synonyms

CESC1
Links

HGNC:27411

NCBI Gene ID: 256126

UniProt: Q6PIF2
Chr Location

19p13.13; chr19:12898786-12919306 (-) GRCh38

MGI Vertebrate Homology

Syce2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: SYCE2
Gene Tree

Syce2

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
49 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

5
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Syce2
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homogyzous for a null mutation are infertile with decreases in testis and ovary weights, arrest of spermatogenesis, and abnormal meiosis.

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All GO Annotations

21
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

605
Tissues

3
cDNA Data

8
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase syce2

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All Sequences

49
RefSeq

7
UniProt

4
CCDS

CCDS22481.1, CCDS52620.1

Ensembl

ENSMUSG00000003824 (Evidence)
NCBI Gene

71846

			Length	Strain/Species	Flank
genomic	71846	NCBI Gene Model \| MGI Sequence Detail	15336	C57BL/6J	± kb
transcript	NM_001168244	RefSeq \| MGI Sequence Detail	1230	C57BL/6
polypeptide	Q505B8	UniProt \| EBI \| MGI Sequence Detail	171	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015860 synaptonemal complex central element protein 2

(term hierarchy)
InterPro Domains

IPR034609 Synaptonemal complex central element protein 2

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All nucleic 8

cDNA 8

Antibodies 3

Microarray probesets 3

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MGI:2140728

Summaries

All 87

Developmental Gene Expression 8

Gene Ontology 12

Phenotypes 49
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)

TSS for Syce2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78454	Chr8:85598698-85598704 (+)	-39 bp
Tssr78455	Chr8:85598734-85598741 (+)	-2 bp
Tssr78456	Chr8:85598787-85598797 (+)	52 bp
Tssr78457	Chr8:85598816-85598870 (+)	103 bp
Tssr78458	Chr8:85599395-85599403 (+)	659 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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