Hormad2^tm1.2Atot
Targeted Allele Detail

Summary

• Symbol: Hormad2^tm1.2Atot
• Name: HORMA domain containing 2; targeted mutation 1.2, Attila Toth
• MGI ID: MGI:5427605
• Synonyms: Hormad2^-, Hormad2^deletion
• Gene: Hormad2 Location: Chr11:4295814-4391105 bp, - strand Genetic Position: Chr11, 2.94 cM, cytoband A1
• Alliance: Hormad2^tm1.2Atot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183982
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked construct, consisting of a splice acceptor site, IRES-LacZ neo cassette and a pgk-BSD (blasticidin resistance gene) cassette, and a loxP site were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 4 via homologous recombination. Flp and cre mediated recombination removed the construct and exon 4, respectively. (J:183982)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hormad2 Mutation: 32 strains or lines available

References

• Original: J:183982 Wojtasz L, et al., Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev. 2012 May 1;26(9):958-73
• All: 2 reference(s)