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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hormad2tm1.2Atot
targeted mutation 1.2, Attila Toth
MGI:5427605
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hormad2tm1.2Atot/Hormad2tm1.2Atot involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL MGI:5427612
cx2
Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad2tm1.2Atot/Hormad2tm1.2Atot
involves: 129 * BALB/c * C57BL/6 * SJL MGI:5427616
cx3
Hormad2tm1.2Atot/Hormad2tm1.2Atot
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL MGI:5427615


Genotype
MGI:5427612
hm1
Allelic
Composition
Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad2tm1.2Atot mutation (0 available); any Hormad2 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female fertility is normal
• small but significant increase in the frequency of univalent containing metaphase I oocytes
• small but significant increase in the frequency of univalent containing metaphase I oocytes
• slightly lower median foci numbers of RAD51, DMC1, and RPA in spermatocytes indicating a potential role in double strand break formation or repair
• incomplete and spatially limited sex body formation and an increase in the frequency of sex chromosome pairing defects
• expression analysis indicates a failure of meiotic sex chromosome inactivation
• spermatocytes undergo apoptosis at a stage equivalent to mid-pachytene by the end of the epithelial cycle stage IV of testis tubules
• stage IV arrest

cellular
• small but significant increase in the frequency of univalent containing metaphase I oocytes
• small but significant increase in the frequency of univalent containing metaphase I oocytes
• slightly lower median foci numbers of RAD51, DMC1, and RPA in spermatocytes indicating a potential role in double strand break formation or repair
• incomplete and spatially limited sex body formation and an increase in the frequency of sex chromosome pairing defects
• expression analysis indicates a failure of meiotic sex chromosome inactivation
• spermatocytes undergo apoptosis at a stage equivalent to mid-pachytene by the end of the epithelial cycle stage IV of testis tubules




Genotype
MGI:5427616
cx2
Allelic
Composition
Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic
Background
involves: 129 * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (16 available)
Hormad2tm1.2Atot mutation (0 available); any Hormad2 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

cellular




Genotype
MGI:5427615
cx3
Allelic
Composition
Hormad2tm1.2Atot/Hormad2tm1.2Atot
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad2tm1.2Atot mutation (0 available); any Hormad2 mutation (32 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• oocyte numbers are similar to wild-type females
• significant decrease in the frequency of pseudo-sex bodies compared to mutant mice wild-type for Hormad2

cellular
• significant decrease in the frequency of pseudo-sex bodies compared to mutant mice wild-type for Hormad2





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory