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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Spo11
SPO11 initiator of meiotic double stranded breaks
MGI:1349669
37 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Spo11tm1.1Gvpc/Spo11tm1.1Gvpc
involves: C57BL/6
abnormal double-strand DNA break repair J:202231
abnormal uterus development J:202231
absent mature ovarian follicles J:202231
small ovary J:202231
Spo11tm1.1Gvpc/Spo11tm3Rdco
involves: C57BL/6
abnormal double-strand DNA break repair J:202231
abnormal X-Y chromosome synapsis during male meiosis J:202231
arrest of male meiosis J:202231
azoospermia J:202231
decreased mature ovarian follicle number J:202231
early reproductive senescence J:202231
male infertility J:202231
small ovary J:202231
small testis J:202231
Spo11tm1Bdm/Spo11tm1Bdm
involves: 129
abnormal double-strand DNA break repair J:199075
abnormal meiosis J:199075
abnormal oogenesis J:199075
abnormal synaptonemal complex J:199075
abnormal X-Y chromosome synapsis during male meiosis J:199075
arrest of spermatogenesis J:199075
female infertility J:199075
male infertility J:199075
Spo11tm1Mjn/Spo11+
B6.Cg-Spo11tm1Mjn
abnormal double-strand DNA break repair J:280261
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ
abnormal female meiosis J:192634
abnormal meiosis J:183982
abnormal synaptonemal complex J:236226
decreased oocyte number J:183982, J:192634
decreased ovary weight J:192634
small ovary J:192634
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6
abnormal female meiosis J:65880
abnormal male meiosis J:65880
abnormal oogenesis J:65880
abnormal ovary morphology J:65880
abnormal primordial ovarian follicle morphology J:65880
abnormal spermatid morphology J:65880
abnormal spermatogenesis J:65880
arrest of spermatogenesis J:65880
azoospermia J:65880
decreased mature ovarian follicle number J:65880
decreased oocyte number J:65880
decreased testis weight J:65880
female infertility J:65880
normal immune system phenotype J:74754
impaired ovarian folliculogenesis J:65880
male infertility J:65880
small ovary J:65880
small seminiferous tubules J:65880
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6J
abnormal chromosomal synapsis J:209347
abnormal double-strand DNA break repair J:209347
abnormal male meiosis J:187173, J:209347
arrest of male meiosis J:209347
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6JOlaHsd
abnormal female meiosis J:173089
arrest of spermatogenesis J:173089
decreased oocyte number J:173089
oocyte degeneration J:173089
Spo11tm1Nki/Spo11tm1Nki
involves: 129P2/OlaHsd
abnormal female meiosis J:177475
abnormal male meiosis J:177475
abnormal meiosis J:177475
abnormal synaptonemal complex J:177475
female infertility J:177475
male infertility J:177475
Spo11tm1Rdco/Spo11tm1Rdco
involves: 129 * C57BL/6
arrest of male meiosis J:140402
Spo11tm1Rdco/Spo11tm1Rdco
involves: 129S6/SvEvTac
abnormal female meiosis J:65881
abnormal female reproductive system morphology J:65881
abnormal fertility/fecundity J:65881
abnormal gametogenesis J:65881
abnormal male meiosis J:194067
abnormal male reproductive system morphology J:65881
abnormal ovary morphology J:65881
abnormal reproductive system morphology J:65881
abnormal seminiferous tubule morphology J:65881
abnormal spermatogenesis J:65881
arrest of male meiosis J:65881
female infertility J:65881
male infertility J:65881
small testis J:65881
Spo11tm2.1Rdco/Spo11tm2.1Rdco
B6.129S6-Spo11tm2.1Rdco
abnormal male meiosis J:194067
arrest of male meiosis J:194067
Spo11tm2b(KOMP)Wtsi/Spo11tm2b(KOMP)Wtsi
C57BL/6N-Spo11tm2b(KOMP)Wtsi/Bay
abnormal spleen morphology J:211773
Spo11tm3Rdco/Spo11tm3Rdco
involves: C57BL/6
abnormal reproductive system morphology J:202231

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory