Spo11^tm1Nki
Targeted Allele Detail

Summary

• Symbol: Spo11^tm1Nki
• Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1, The Netherlands Cancer Institute
• MGI ID: MGI:4398954
• Gene: Spo11 Location: Chr2:172819493-172835369 bp, + strand Genetic Position: Chr2, 95.64 cM, cytoband H4
• Alliance: Spo11^tm1Nki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177475
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: The codon encoding tyrosine at position 100 in the catalytic domain is substituted by a codon encoding phenylanaline. (J:177475)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spo11 Mutation: 20 strains or lines available

References

• Original: J:177475 Inagaki A, et al., Meiotic functions of RAD18. J Cell Sci. 2011 Aug 15;124(Pt 16):2837-50
• All: 1 reference(s)