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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Trp73
transformation related protein 73
MGI:1336991
72 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
involves: 129S1/Sv * 129X1/SvJ
abnormal choroid plexus morphology J:153209
abnormal cortical marginal zone morphology J:153209
abnormal forebrain development J:153209
abnormal hypothalamus morphology J:153209
abnormal trigeminal ganglion morphology J:153209
abnormal vomeronasal organ morphology J:153209
decreased Cajal-Retzius cell number J:153209
increased neuron apoptosis J:153209
reduced fertility J:153209
Trp73tm1Fmc/Trp73+
involves: 129S4/SvJae * C57BL/6
increased hemangiosarcoma incidence J:98958
increased lung adenocarcinoma incidence J:98958
increased lung adenoma incidence J:98958
increased malignant tumor incidence J:98958
increased T cell derived lymphoma incidence J:98958
increased tumor incidence J:98958
premature death J:98958
Trp73tm1Fmc/Trp73tm1Fmc
involves: 129S4/SvJae
abnormal cerebrospinal fluid production J:60896
abnormal dendrite morphology J:180144
abnormal dentate gyrus morphology J:60896, J:180144
abnormal hippocampal mossy fiber morphology J:180144
abnormal hippocampus CA3 region morphology J:180144
abnormal hippocampus development J:60896
abnormal hippocampus morphology J:180144
abnormal hippocampus neuron morphology J:180144
abnormal vomeronasal organ morphology J:60896
absent Cajal-Retzius cell J:60896
absent enterocytes J:60896
cachexia J:60896
chronic inflammation J:60896
conjunctivitis J:60896
decreased body size J:60896
dilated lateral ventricles J:60896
distended ileum J:60896
domed cranium J:60896
excessive digestive secretion J:60896
female infertility J:60896
gastrointestinal hemorrhage J:60896
hydroencephaly J:60896
increased susceptibility to bacterial infection J:60896
increased susceptibility to otitis media J:60896
intracranial hemorrhage J:60896
intraventricular hemorrhage J:60896
normal neoplasm J:60896
non-obstructive hydrocephaly J:60896
periorbital edema J:60896
postnatal lethality, incomplete penetrance J:60896
reduced male mating frequency J:60896
rhinitis J:60896
sinus inflammation J:60896
submission towards male mice J:60896
Trp73tm1Fmc/Trp73tm1Fmc
involves: 129S4/SvJae * C57BL/6
increased lung adenocarcinoma incidence J:98958
premature death J:98958
Trp73tm1Mak/Trp73+
involves: 129P2/OlaHsd * C57BL/6J
increased carcinoma incidence J:142848
increased hemangiosarcoma incidence J:142848
increased lung adenocarcinoma incidence J:142848
increased lymphoma incidence J:142848
increased T cell derived lymphoma incidence J:142848
Trp73tm1Mak/Trp73tm1Mak
involves: 129P2/OlaHsd
abnormal dendrite morphology J:180144
Trp73tm1Mak/Trp73tm1Mak
involves: 129P2/OlaHsd * C57BL/6J
abnormal cell cycle J:142848
abnormal chromosome number J:142848
abnormal dentate gyrus morphology J:142848
abnormal embryo development J:142848
abnormal female meiosis J:142848
abnormal hippocampus morphology J:142848
abnormal meiotic spindle morphology J:142848
abnormal ovarian follicle number J:142848
abnormal ovulation J:142848
anovulation J:142848
decreased oocyte number J:142848
female infertility J:142848
increased carcinoma incidence J:142848
increased incidence of tumors by chemical induction J:142848
increased lung adenocarcinoma incidence J:142848
increased lymphoma incidence J:142848
increased T cell derived lymphoma incidence J:142848
male infertility J:142848
maternal effect J:142848
polyploidy J:142848
premature death J:142848
prenatal lethality, incomplete penetrance J:142848
Trp73tm2Mak/Trp73tm2Mak
either: B6.129P2-Trp73tm2Mak or (involves: 129P2/OlaHsd * C57BL/6J)
abnormal cerebral cortex morphology J:157905
decreased neuron number J:157905
increased cellular sensitivity to gamma-irradiation J:157905
increased physiological sensitivity to xenobiotic J:157905
increased sensitivity to induced cell death J:157905
increased thymocyte apoptosis J:157905
neurodegeneration J:157905
prenatal lethality, incomplete penetrance J:157905

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory