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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Dnmt3a
DNA methyltransferase 3A
MGI:1261827
9 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
ApcMin/Apc+
Col1a1tm12(tetO-Dnmt3a_i1)Jae/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
involves: 129S4/SvJae * C57BL/6 * C57BL/6J
normal neoplasm J:127808
Dnmt3atm1Enl/Dnmt3atm1Enl
Dnmt3btm1Enl/Dnmt3btm1Enl
involves: 129S4/SvJae * C57BL/6
absent somites J:58298
embryonic lethality, complete penetrance J:58298
incomplete embryo turning J:58298
Dnmt3atm1Jae/Dnmt3atm1Jae
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Tg(Ins2-cre)23Herr/0
involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL
abnormal pancreatic beta cell differentiation J:177838
Dnmt3atm1Jae/Dnmt3atm1Jae
Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Tg(Ins2-cre)23Herr/0
involves: Black Swiss * C57BL/6 * CBA/J * SJL
decreased pancreatic beta cell number J:177838
increased pancreatic alpha cell number J:177838
Dnmt3atm1Trow/Dnmt3a+
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow Dnmt3atm1Trow Tg(Mx1-cre)1Cgn
abnormal bone marrow cell physiology J:272803
Dnmt3atm2Enl/Dnmt3atm2Enl
Dnmt3btm1Enl/Dnmt3btm1Enl
involves: 129S4/SvJae * C57BL/6
abnormal DNA methylation J:116773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory