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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Bmpr2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
MGI:1095407
58 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Bmpr2b2b2556Clo/Bmpr2b2b2556Clo
C57BL/6J-Bmpr2b2b2556Clo
abnormal myocardium compact layer morphology J:175213
absent heart valves J:175213
atrioventricular septal defect J:175213
hydronephrosis J:175213
muscular ventricular septal defect J:175213
persistent truncus arteriosus type i J:175213
persistent truncus arteriosus type iv J:175213
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
involves: 129S4/SvJae * C57BL/6 * FVB/N
no abnormal phenotype detected J:97109
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(Acvrl1-cre)L1Spo/0
involves: 129S4/SvJae * FVB
abnormal lung vasculature morphology J:158116
abnormal pulmonary artery morphology J:158116
abnormal thrombosis J:158116
abnormal vascular smooth muscle physiology J:158116
artery occlusion J:158116
heart right ventricle hypertrophy J:158116
increased lung endothelial cell proliferation J:158116
increased pulmonary artery pressure J:158116
pulmonary hypertension J:158116
Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Tg(KRT14-cre)1Ipc/0
involves: 129S4/SvJae * C57BL/6 * SJL
abnormal hair medulla J:189569
abnormal hair medullary septa cells J:189569
abnormal hair shaft melanin granule distribution J:189569
normal integument phenotype J:189569
Bmpr2tm1.1Enl/Bmpr2tm1.2Enl
H2afvTg(Wnt1-cre)11Rth/0
involves: 129S4/SvJae * C57BL/6J * CBA/J
abnormal ophthalmic nerve morphology J:206541
normal nervous system phenotype J:206541
Bmpr2tm1.1Enl/Bmpr2tm1Kmi
Tg(KRT14-cre)1Ipc/0
involves: 129S4/SvJae * C57BL/6 * SJL
normal no abnormal phenotype detected J:189569
Bmpr2tm1.1Pley/Bmpr2+
B6.Cg-Bmpr2tm1.1Pley
normal cardiovascular system phenotype J:209027
Bmpr2tm1.1Pley/Bmpr2tm1.1Pley
B6.Cg-Bmpr2tm1.1Pley
embryonic lethality between implantation and placentation, incomplete penetrance J:209027
Bmpr2tm1.2Enl/Bmpr2tm1.2Enl
involves: 129S4/SvJae * C57BL/6
embryonic growth retardation J:97109
embryonic lethality between implantation and somite formation, complete penetrance J:97109
Bmpr2tm1Enl/Bmpr2tm1Enl
involves: 129S4/SvJae * C57BL/6
no abnormal phenotype detected J:97109
Bmpr2tm1Kmi/Bmpr2+
involves: 129S4/SvJae
abnormal sternocostal joint morphology J:95124
vertebral transformation J:95124
Bmpr2tm1Kmi/Bmpr2+
involves: 129S4/SvJae * C57BL/6
abnormal lung vasculature morphology J:98219
abnormal pulmonary alveolus morphology J:98219
abnormal pulmonary artery morphology J:98219
increased pulmonary artery pressure J:98219
increased pulmonary vascular resistance J:98219
pulmonary hypertension J:98219
Bmpr2tm1Kmi/Bmpr2+
involves: 129S4/SvJae * C57BL/6J
abnormal leukocyte physiology J:117167
abnormal lung vasculature morphology J:117167
increased vasoconstriction J:117167
perinatal lethality, incomplete penetrance J:117167
prenatal lethality, incomplete penetrance J:117167
pulmonary hypertension J:117167
Bmpr2tm1Kmi/Bmpr2tm1Kmi
involves: 129S4/SvJae * C57BL/6J
abnormal egg cylinder morphology J:61931
abnormal embryonic epiblast morphology J:61931
abnormal embryonic-extraembryonic boundary morphology J:61931
abnormal rostral-caudal axis patterning J:61931
absent mesoderm J:61931
disorganized embryonic tissue J:61931
disorganized extraembryonic tissue J:61931
embryonic growth arrest J:61931
embryonic growth retardation J:61931
embryonic lethality during organogenesis, complete penetrance J:61931
failure of primitive streak formation J:61931
failure to gastrulate J:61931
Bmpr2tm1Kml/Bmpr2tm1Kml
either: (involves: 129X1/SvJ * BALB/cJ) or (involves: 129X1/SvJ * C57BL/6J)
abnormal interventricular septum morphology J:80024
abnormal semilunar valve morphology J:80024
absent vitelline blood vessels J:80024
decreased rib number J:80024
delayed bone ossification J:80024
interrupted aortic arch J:80024
lethality throughout fetal growth and development, complete penetrance J:80024
Bmpr2tm1Mmue/Bmpr2+
B6.129S1-Bmpr2tm1Mmue
abnormal pulmonary artery morphology J:224752
increased right ventricle systolic pressure J:224752
increased vascular permeability J:224752
pulmonary hypertension J:224752
Bmpr2tm1Mmue/Bmpr2tm1Mmue
B6.129S1-Bmpr2tm1Mmue
lethality, complete penetrance J:224752
Tg(Tagln-rtTA)E1Jwst/0
Tg(tetO-Bmpr2*R899X)#Jwst/0
involves: FVB/N
abnormal lung vasculature morphology J:164503
heart right ventricle hypertrophy J:164503
increased body weight J:164503
increased right ventricle systolic pressure J:164503

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory