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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nfil3
nuclear factor, interleukin 3, regulated
MGI:109495
56 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Commd10Tg(Vav1-icre)A2Kio/0
Nfil3tm1.2Kubo/Nfil3tm1.2Kubo
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
decreased dendritic cell number J:334296
Nfil3tm1.1(KOMP)Vlcg/Nfil3tm1.1(KOMP)Vlcg
C57BL/6N-Nfil3tm1.1(KOMP)Vlcg/Ucd
abnormal cecum morphology J:211773
abnormal cornea morphology J:211773
abnormal pancreas morphology J:211773
abnormal spleen morphology J:211773
abnormal thymus morphology J:211773
decreased bone mineral content J:211773
enlarged spleen J:211773
increased spleen weight J:211773
preweaning lethality, incomplete penetrance J:211773
small thymus J:211773
Nfil3tm1.1Brad/Nfil3+
B6.Cg-Nfil3tm1.1Brad
decreased NK cell number J:152774
Nfil3tm1.1Brad/Nfil3tm1.1Brad
B6.Cg-Nfil3tm1.1Brad
abnormal NK cell differentiation J:152774
decreased interferon-gamma secretion J:152774
decreased NK cell number J:152774
normal immune system phenotype J:152774
impaired natural killer cell mediated cytotoxicity J:152774
increased memory T cell number J:152774
increased NK T cell number J:152774
Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
B6.Cg-Nfil3tm1.1Kubo
abnormal interleukin secretion J:184570
decreased body weight J:172134
decreased interleukin-9 secretion J:184570
decreased interleukin-10 secretion J:172134, J:184570
decreased interleukin-13 secretion J:172134, J:184570
decreased interleukin-17 secretion J:184570
diarrhea J:172134
normal digestive/alimentary phenotype J:340220
increased susceptibility to experimental autoimmune encephalomyelitis J:172134
increased susceptibility to induced colitis J:172134
Nfil3tm1.2Kubo/Nfil3tm1.2Kubo
Tg(Itgax-cre)1-1Reiz/0
involves: 129 * C57BL/6 * CBA
normal hematopoietic system phenotype J:334296
normal immune system phenotype J:334296
Nfil3tm1Look/Nfil3tm1Look
B6.129X1-Nfil3tm1Look
abnormal NK cell differentiation J:155677
decreased interferon-gamma secretion J:155677
decreased NK cell number J:155677
impaired natural killer cell mediated cytotoxicity J:155677
Nfil3tm1Look/Nfil3tm1Look
involves: 129X1/SvJ
normal immune system phenotype J:209365
Nfil3tm1Pbro/Nfil3tm1Pbro
B6.129S6-Nfil3tm1Pbro
abnormal circulating cytokine level J:209365
abnormal colon goblet cell morphology J:209365
abnormal colon morphology J:209365
abnormal cytokine secretion J:209365
abnormal leukocyte morphology J:209365
abnormal plasma cell morphology J:209365
colitis J:209365
decreased NK cell number J:209365
increased circulating interferon-gamma level J:209365
increased circulating interleukin-10 level J:209365
increased circulating interleukin-12b level J:209365
increased circulating interleukin-17 level J:209365
increased circulating tumor necrosis factor level J:209365
increased interferon-gamma secretion J:209365
increased interleukin-10 secretion J:209365
increased interleukin-12b secretion J:209365
increased interleukin-17 secretion J:209365
increased macrophage cytokine production J:209365
increased T-helper 17 cell number J:209365
increased tumor necrosis factor secretion J:209365
intestinal ulcer J:209365
rectal prolapse J:209365
Nfil3tm1Pbro/Nfil3tm1Pbro
involves: 129S6/SvEvTac * C57BL/6
abnormal class switch recombination J:156521
decreased IgE level J:156521
decreased IgG1 level J:156521
decreased interleukin-4 secretion J:156521
normal immune system phenotype J:156521
Tg(Igh-Nfil3)#Kubo/0
B6.Cg-Tg(Igh-Nfil3)#Kubo
increased interleukin-3 secretion J:172134
increased interleukin-10 secretion J:172134
increased interleukin-13 secretion J:172134

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory