Bcl2l2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bcl2l2
BCL2-like 2
MGI:108052

22 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor} involves: 129S5/SvEvBrd	abnormal CNS synapse formation	J:137190
	abnormal motor learning	J:137190
	abnormal neuron mitochondrial morphology	J:137190
	abnormal Purkinje cell dendrite morphology	J:137190
	abnormal seminiferous tubule morphology	J:46386
	decreased male germ cell number	J:46386
	decreased seminal vesicle weight	J:46386
	increased circulating follicle stimulating hormone level	J:46386
	male infertility	J:46386
	small testis	J:46386
Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor} involves: 129S5/SvEvBrd * C57BL/6J	abnormal Sertoli cell barrier morphology	J:70212
	absent Leydig cells	J:70212
	decreased germ cell number	J:70212
	decreased seminal vesicle weight	J:70212
	decreased Sertoli cell number	J:70212
	decreased testis weight	J:70212
	increased Leydig cell number	J:70212
	small seminiferous tubules	J:70212
Bcl2l2^tm1Sco/Bcl2l2^tm1Sco involves: 129S1/Sv * C57BL/6 * FVB/N	abnormal reproductive system morphology	J:50338
	abnormal seminiferous tubule epithelium morphology	J:50338
	azoospermia	J:50338
	decreased Sertoli cell number	J:50338
	increased male germ cell apoptosis	J:50338
	male infertility	J:50338
	multinucleated giant male germ cells	J:50338
	small seminiferous tubules	J:50338

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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