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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Traf3
TNF receptor-associated factor 3
MGI:108041
45 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Traf3tm1Rbr/Traf3tm1Rbr
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal B cell physiology J:132877
increased follicular B cell number J:132877
increased marginal zone B cell number J:132877
lymph node hyperplasia J:132877
Tg(Lck-cre)I57Jxm/?
Traf3tm1Rbr/Traf3tm1Rbr
involves: C57BL/6 * ICR * SJL 		abnormal T cell physiology J:132877
decreased CD4-positive, alpha-beta T cell number J:132877
decreased CD8-positive, alpha-beta T cell number J:132877
Traf3m1Btlr/Traf3m1Btlr
C57BL/6J-Traf3m1Btlr 		decreased mature B cell number J:212064
impaired humoral immune response J:212064
Traf3m2Btlr/Traf3m2Btlr
C57BL/6J-Traf3m2Btlr 		decreased IgG level J:217797
decreased response to antigen J:217797
Traf3tm1Bal/Traf3tm1Bal
involves: 129S4/SvJae * C57BL/6J 		abnormal B cell differentiation J:37065
abnormal T cell physiology J:37065
decreased body size J:37065
decreased body weight J:37065
decreased double-positive T cell number J:37065
decreased leukocyte cell number J:37065
decreased thymocyte number J:37065
hypoglycemia J:37065
increased circulating corticosterone level J:37065
postnatal lethality, complete penetrance J:37065
spleen hypoplasia J:37065
Traf3tm1Bshp/Traf3tm1Bshp
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL 		abnormal adaptive immunity J:124329
abnormal immune system organ morphology J:124329
abnormal immune system physiology J:124329
abnormal kidney morphology J:124329
abnormal leukocyte morphology J:124329
abnormal liver morphology J:124329
abnormal lymph node B cell domain morphology J:124329
abnormal spleen germinal center morphology J:124329
autoimmune response J:124329
decreased B cell apoptosis J:124329
decreased physiological sensitivity to xenobiotic J:124329
decreased T cell number J:124329
enlarged lymph nodes J:124329
enlarged spleen J:124329
increased anti-double stranded DNA antibody level J:124329
increased B cell number J:124329
increased follicular B cell number J:124329
increased IgA level J:124329
increased IgG2a level J:124329
increased IgG2b level J:124329
increased IgG3 level J:124329
increased IgG level J:124329
increased IgM level J:124329
increased marginal zone B cell number J:124329
increased spleen white pulp amount J:124329
increased transitional stage B cell number J:124329
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory