121 phenotypes from 13 alleles in 18 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd79atm1(cre)Reth/Cd79a+ Inpp5dtm1Rav/Inpp5dtm1Rav involves: 129 * BALB/c * C57BL/6	increased anti-chromatin antibody level	J:178833
	increased anti-double stranded DNA antibody level	J:178833
	increased anti-nuclear antigen antibody level	J:178833
	increased anti-single stranded DNA antibody level	J:178833
	increased autoantibody level	J:178833
	increased IgG level	J:178833
	increased susceptibility to systemic lupus erythematosus	J:178833
	premature death	J:178833
Inpp5del20/Inpp5del20 B6.129-Inpp5del20	abnormal erythropoiesis	J:173266
	abnormal lymphocyte cell number	J:173266
	abnormal pulmonary alveolus morphology	J:173266
	anemia	J:173266
	decreased body size	J:173266
	decreased lymphocyte cell number	J:173266
	decreased pre-B cell number	J:173266
	decreased thymocyte number	J:173266
	enlarged spleen	J:173266
	increased circulating interleukin-6 level	J:173266
	increased IgG2a level	J:173266
	increased IgM level	J:173266
	increased immunoglobulin level	J:173266
	increased macrophage cell number	J:173266
	postnatal growth retardation	J:173266
	premature death	J:173266
	respiratory failure	J:173266
	small thymus	J:173266
	thrombocytopenia	J:173266
Inpp5dm1Anu/Inpp5dm1Anu C57BL/6JAnu-Inpp5dm1Anu	increased B cell derived lymphoma incidence	J:104190
	lung hemorrhage	J:104190
	lung inflammation	J:104190
Inpp5dm1Btlr/Inpp5dm1Btlr C57BL/6J-Inpp5dm1Btlr	abnormal B cell differentiation	J:140987
	abnormal eosinophil physiology	J:140987
	abnormal neutrophil physiology	J:140987
	cachexia	J:140987
	decreased cytotoxic T cell cytolysis	J:140987
	enlarged spleen	J:140987
	enlarged thymus	J:140987
	impaired natural killer cell mediated cytotoxicity	J:140987
	premature death	J:140987
Inpp5dm2Btlr/Inpp5dm2Btlr C57BL/6J-Inpp5dm2Btlr	decreased B cell number	J:216053
Inpp5dM3Btlr/Inpp5d+ C57BL/6J-Inpp5dM3Btlr	decreased NK cell number	J:254907
Inpp5dm4Btlr/Inpp5dm4Btlr C57BL/6J-Inpp5dm4Btlr	increased interferon-beta secretion	J:272854
	increased tumor necrosis factor secretion	J:272854
Inpp5dm5Btlr/Inpp5dm5Btlr C57BL/6J-Inpp5dm5Btlr	abnormal CD8-positive, alpha-beta T cell differentiation	J:272856
	abnormal lymphocyte morphology	J:272856
	abnormal T cell differentiation	J:272856
	decreased alpha-beta T cell number	J:272856
	decreased B cell number	J:272856
	decreased body weight	J:272856
	decreased CD4-positive, alpha-beta T cell number	J:272856
	decreased CD8-positive, alpha-beta T cell number	J:272856
	decreased CD8-positive, naive alpha-beta T cell number	J:272856
	decreased heart rate	J:272856
	decreased NK cell number	J:272856
	increased B-1 B cell number	J:272856
	increased CD8-positive, alpha-beta T cell number	J:272856
	increased central memory CD8 positive, alpha-beta T cell number	J:272856
	increased effector memory CD4-positive, alpha-beta T cell number	J:272856
	increased effector memory CD8-positive, alpha-beta T cell number	J:272856
Inpp5dtm1.1Wgk/Inpp5dtm1.1Wgk involves: 129S6/SvEvTac * C57BL/6J	abnormal leukocyte physiology	J:94861
	abnormal mononuclear cell differentiation	J:94861
	abnormal NK cell morphology	J:95215
	decreased susceptibility to graft versus host disease	J:94861, J:95215
	increased dendritic cell number	J:94861
	increased monocyte cell number	J:94861
	increased NK cell number	J:95215
Inpp5dtm1Dmt/Inpp5dtm1Dmt B6.129P2/OlaHsd-Inpp5dtm1Dmt	abnormal pulmonary alveolus morphology	J:173266
	anemia	J:173266
	decreased lymphocyte cell number	J:173266
	decreased pre-B cell number	J:173266
	increased circulating interleukin-6 level	J:173266
	premature death	J:173266
	respiratory failure	J:173266
	thrombocytopenia	J:173266
Inpp5dtm1Dmt/Inpp5dtm1Dmt involves: 129P2/OlaHsd	abnormal leukocyte physiology	J:77739
	decreased B cell number	J:77739
	enlarged lymph nodes	J:77739
	enlarged spleen	J:77739
	increased leukocyte cell number	J:77739
	premature death	J:77739
Inpp5dtm1Dmt/Inpp5dtm1Dmt involves: 129P2/OlaHsd * C57BL/6	abnormal blood coagulation	J:121283
	abnormal platelet activation	J:121283
	decreased platelet aggregation	J:121283
	increased bleeding time	J:121283
Inpp5dtm1Rav/Inpp5dtm1.1Rav Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * C57BL/6	abnormal spleen marginal zone macrophage morphology	J:119256
	absent marginal zone B cells	J:119256
	enlarged spleen	J:119256
Inpp5dtm1Rav/Inpp5dtm1Rav Tg(Cd4-cre)1Cwi/? involves: C57BL/6 * DBA/2	abnormal cytotoxic T cell physiology	J:122796
	abnormal humoral immune response	J:122796
	abnormal interferon level	J:122796
	abnormal interleukin secretion	J:122796
	abnormal lymph node germinal center morphology	J:122796
	decreased susceptibility to parasitic infection	J:122796
Inpp5dtm1Rkh/Inpp5dtm1Rkh involves: 129S1/Sv * 129X1/SvJ	abnormal B cell physiology	J:110864
	abnormal bone marrow cell physiology	J:110864
	abnormal bone structure	J:78771
	abnormal CD4-positive, alpha-beta T cell physiology	J:110864
	abnormal CD8-positive, alpha-beta T cell physiology	J:110864
	abnormal cell-mediated immunity	J:110864
	abnormal long bone metaphysis morphology	J:78771
	abnormal long bone morphology	J:78771
	abnormal macrophage chemotaxis	J:110864
	abnormal osteoclast differentiation	J:78771
	abnormal osteoclast morphology	J:78771
	abnormal osteoclast physiology	J:78771
	abnormal skeleton morphology	J:78771
	abnormal skeleton physiology	J:78771
	abnormal T cell physiology	J:110864
	abnormal trabecular bone morphology	J:78771
	decreased apoptosis	J:78771
	decreased bone mineral density	J:78771
	decreased bone strength	J:78771
	decreased bone trabecula number	J:78771
	decreased compact bone thickness	J:78771
	decreased trabecular bone thickness	J:78771
	decreased trabecular bone volume	J:78771
	increased circulating interleukin-6 level	J:78771
	increased mast cell degranulation	J:120426
	increased osteoclast cell number	J:78771
	pulmonary edema	J:100868
	short femur	J:78771
Inpp5dtm1Rkh/Inpp5dtm1Rkh involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal ileum morphology	J:173301
	abnormal interleukin level	J:173301
	abnormal intestinal goblet cell morphology	J:173301
	abnormal intestinal smooth muscle morphology	J:173301
	abnormal intestine morphology	J:173301
	abnormal myelopoiesis	J:117320
	decreased pro-B cell number	J:117320
	ileum inflammation	J:173301
	increased circulating interleukin-6 level	J:117320
	intestinal inflammation	J:173301
Inpp5dtm1Rkh/Inpp5dtm1Rkh involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal definitive hematopoiesis	J:48193
	abnormal granulocyte differentiation	J:48193
	abnormal lung morphology	J:48193
	abnormal lymphopoiesis	J:48193
	abnormal macrophage chemotaxis	J:48193
	abnormal monocyte differentiation	J:48193
	decreased body weight	J:48193
	decreased bone marrow cell number	J:48193
	decreased lymphocyte cell number	J:48193
	increased monocyte cell number	J:48193
	increased neutrophil cell number	J:48193
	increased spleen weight	J:48193
	premature death	J:48193
	spleen hyperplasia	J:48193
Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn/0 B6.Cg-Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn	abnormal leukocyte physiology	J:144110
	abnormal myeloid leukocyte morphology	J:144110
Inpp5dtm1Wgk/Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn/0 B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn	decreased susceptibility to graft versus host disease	J:144110