About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Inpp5d
inositol polyphosphate-5-phosphatase D
MGI:107357
121 phenotypes from 13 alleles in 18 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Cd79atm1(cre)Reth/Cd79a+
Inpp5dtm1Rav/Inpp5dtm1Rav
involves: 129 * BALB/c * C57BL/6
increased anti-chromatin antibody level J:178833
increased anti-double stranded DNA antibody level J:178833
increased anti-nuclear antigen antibody level J:178833
increased anti-single stranded DNA antibody level J:178833
increased autoantibody level J:178833
increased IgG level J:178833
increased susceptibility to systemic lupus erythematosus J:178833
premature death J:178833
Inpp5del20/Inpp5del20
B6.129-Inpp5del20
abnormal erythropoiesis J:173266
abnormal lymphocyte cell number J:173266
abnormal pulmonary alveolus morphology J:173266
anemia J:173266
decreased body size J:173266
decreased lymphocyte cell number J:173266
decreased pre-B cell number J:173266
decreased thymocyte number J:173266
enlarged spleen J:173266
increased circulating interleukin-6 level J:173266
increased IgG2a level J:173266
increased IgM level J:173266
increased immunoglobulin level J:173266
increased macrophage cell number J:173266
postnatal growth retardation J:173266
premature death J:173266
respiratory failure J:173266
small thymus J:173266
thrombocytopenia J:173266
Inpp5dm1Anu/Inpp5dm1Anu
C57BL/6JAnu-Inpp5dm1Anu
increased B cell derived lymphoma incidence J:104190
lung hemorrhage J:104190
lung inflammation J:104190
Inpp5dm1Btlr/Inpp5dm1Btlr
C57BL/6J-Inpp5dm1Btlr
abnormal B cell differentiation J:140987
abnormal eosinophil physiology J:140987
abnormal neutrophil physiology J:140987
cachexia J:140987
decreased cytotoxic T cell cytolysis J:140987
enlarged spleen J:140987
enlarged thymus J:140987
impaired natural killer cell mediated cytotoxicity J:140987
premature death J:140987
Inpp5dm2Btlr/Inpp5dm2Btlr
C57BL/6J-Inpp5dm2Btlr
decreased B cell number J:216053
Inpp5dM3Btlr/Inpp5d+
C57BL/6J-Inpp5dM3Btlr
decreased NK cell number J:254907
Inpp5dm4Btlr/Inpp5dm4Btlr
C57BL/6J-Inpp5dm4Btlr
increased interferon-beta secretion J:272854
increased tumor necrosis factor secretion J:272854
Inpp5dm5Btlr/Inpp5dm5Btlr
C57BL/6J-Inpp5dm5Btlr
abnormal CD8-positive, alpha-beta T cell differentiation J:272856
abnormal lymphocyte morphology J:272856
abnormal T cell differentiation J:272856
decreased alpha-beta T cell number J:272856
decreased B cell number J:272856
decreased body weight J:272856
decreased CD4-positive, alpha beta T cell number J:272856
decreased CD8-positive, alpha-beta T cell number J:272856
decreased CD8-positive, naive alpha-beta T cell number J:272856
decreased heart rate J:272856
decreased NK cell number J:272856
increased B-1 B cell number J:272856
increased CD8-positive, alpha-beta T cell number J:272856
increased central memory CD8 positive, alpha-beta T cell number J:272856
increased effector memory CD4-positive, alpha-beta T cell number J:272856
increased effector memory CD8-positive, alpha-beta T cell number J:272856
Inpp5dtm1.1Wgk/Inpp5dtm1.1Wgk
involves: 129S6/SvEvTac * C57BL/6J
abnormal leukocyte physiology J:94861
abnormal mononuclear cell differentiation J:94861
abnormal NK cell morphology J:95215
decreased susceptibility to graft versus host disease J:94861, J:95215
increased dendritic cell number J:94861
increased monocyte cell number J:94861
increased NK cell number J:95215
Inpp5dtm1Dmt/Inpp5dtm1Dmt
B6.129P2/OlaHsd-Inpp5dtm1Dmt
abnormal pulmonary alveolus morphology J:173266
anemia J:173266
decreased lymphocyte cell number J:173266
decreased pre-B cell number J:173266
increased circulating interleukin-6 level J:173266
premature death J:173266
respiratory failure J:173266
thrombocytopenia J:173266
Inpp5dtm1Dmt/Inpp5dtm1Dmt
involves: 129P2/OlaHsd
abnormal leukocyte physiology J:77739
decreased B cell number J:77739
enlarged lymph nodes J:77739
enlarged spleen J:77739
increased leukocyte cell number J:77739
premature death J:77739
Inpp5dtm1Dmt/Inpp5dtm1Dmt
involves: 129P2/OlaHsd * C57BL/6
abnormal blood coagulation J:121283
abnormal platelet activation J:121283
decreased platelet aggregation J:121283
increased bleeding time J:121283
Inpp5dtm1Rav/Inpp5dtm1.1Rav
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6
abnormal spleen marginal zone macrophage morphology J:119256
absent marginal zone B cells J:119256
enlarged spleen J:119256
Inpp5dtm1Rav/Inpp5dtm1Rav
Tg(Cd4-cre)1Cwi/?
involves: C57BL/6 * DBA/2
abnormal cytotoxic T cell physiology J:122796
abnormal humoral immune response J:122796
abnormal interferon level J:122796
abnormal interleukin secretion J:122796
abnormal lymph node germinal center morphology J:122796
decreased susceptibility to parasitic infection J:122796
Inpp5dtm1Rkh/Inpp5dtm1Rkh
involves: 129S1/Sv * 129X1/SvJ
abnormal B cell physiology J:110864
abnormal bone marrow cell physiology J:110864
abnormal bone structure J:78771
abnormal CD4-positive, alpha-beta T cell physiology J:110864
abnormal CD8-positive, alpha-beta T cell physiology J:110864
abnormal cell-mediated immunity J:110864
abnormal long bone metaphysis morphology J:78771
abnormal long bone morphology J:78771
abnormal macrophage chemotaxis J:110864
abnormal osteoclast differentiation J:78771
abnormal osteoclast morphology J:78771
abnormal osteoclast physiology J:78771
abnormal skeleton morphology J:78771
abnormal skeleton physiology J:78771
abnormal T cell physiology J:110864
abnormal trabecular bone morphology J:78771
decreased apoptosis J:78771
decreased bone mineral density J:78771
decreased bone strength J:78771
decreased bone trabecula number J:78771
decreased compact bone thickness J:78771
decreased trabecular bone thickness J:78771
decreased trabecular bone volume J:78771
increased circulating interleukin-6 level J:78771
increased mast cell degranulation J:120426
increased osteoclast cell number J:78771
pulmonary edema J:100868
short femur J:78771
Inpp5dtm1Rkh/Inpp5dtm1Rkh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal ileum morphology J:173301
abnormal interleukin level J:173301
abnormal intestinal goblet cell morphology J:173301
abnormal intestinal smooth muscle morphology J:173301
abnormal intestine morphology J:173301
abnormal myelopoiesis J:117320
decreased pro-B cell number J:117320
ileum inflammation J:173301
increased circulating interleukin-6 level J:117320
intestinal inflammation J:173301
Inpp5dtm1Rkh/Inpp5dtm1Rkh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal definitive hematopoiesis J:48193
abnormal granulocyte differentiation J:48193
abnormal lung morphology J:48193
abnormal lymphopoiesis J:48193
abnormal macrophage chemotaxis J:48193
abnormal monocyte differentiation J:48193
decreased body weight J:48193
decreased bone marrow cell number J:48193
decreased lymphocyte cell number J:48193
increased monocyte cell number J:48193
increased neutrophil cell number J:48193
increased spleen weight J:48193
premature death J:48193
spleen hyperplasia J:48193
Inpp5dtm1Wgk/Inpp5dtm1.1Wgk
Tg(Mx1-cre)1Cgn/0
B6.Cg-Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn
abnormal leukocyte physiology J:144110
abnormal myeloid leukocyte morphology J:144110
Inpp5dtm1Wgk/Inpp5dtm1Wgk
Tg(Mx1-cre)1Cgn/0
B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn
decreased susceptibility to graft versus host disease J:144110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory