Pml Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pml
promyelocytic leukemia
MGI:104662

25 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Pml^{tm1(PML/RARA)Ley}/Pml⁺ involves: C57BL/6	no abnormal phenotype detected	J:172024
Pml^{tm1(PML/RARA)Ley}/Pml⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	normal hematopoietic system phenotype	J:172024
	increased leukemia incidence	J:172024
Pml^{tm1(PML/RARA)Ley}/Pml⁺ Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	prenatal lethality, complete penetrance	J:172024
Pml^{tm1(PML/RARA)Ley}/Pml⁺ Tg(CMV-cre)1Cgn/0 involves: BALB/cJ * C57BL/6	prenatal lethality, complete penetrance	J:172024
Pml^{tm1(PML/RARA)Ley}/Pml⁺ Tg(CAG-cre/Esr1)5Amc/0 involves: BALB/cJ C57BL/6 * CBA	abnormal hematopoietic stem cell physiology	J:172024
	decreased hematopoietic stem cell number	J:172024
	enlarged spleen	J:172024
Pml^tm1.1Ews/Pml^tm1.1Ews Tg(PML-RARA)556Kog/0 FVB.Cg-Pml^tm1.1Ews Tg(PML-RARA)556Kog	abnormal double-strand DNA break repair	J:262172
	anemia	J:262172
	enlarged spleen	J:262172
	increased acute promyelocytic leukemia incidence	J:262172
	increased leukocyte cell number	J:262172
	thrombocytosis	J:262172
Pml^tm1Ppp/Pml⁺ Trp53^tm3.1Glo/Trp53⁺ B6.129S7(Cg)-Pml^tm1Ppp Trp53^tm3.1Glo	decreased body weight	J:317504
	decreased tumor-free survival time	J:317504
	extramedullary hematopoiesis	J:317504
	hepatosplenomegaly	J:317504
	increased B cell derived lymphoma incidence	J:317504
	increased carcinoma incidence	J:317504
	increased lymphoma incidence	J:317504
	increased osteosarcoma incidence	J:317504
	increased sarcoma incidence	J:317504
	increased T cell derived lymphoma incidence	J:317504
	premature death	J:317504
Pml^tm1Ppp/Pml⁺ Trp53^tm3.1Glo/Trp53^tm3.1Glo B6.129S7(Cg)-Pml^tm1Ppp Trp53^tm3.1Glo	premature death	J:317504
	prenatal lethality, incomplete penetrance	J:317504
Pml^tm1Ppp/Pml^tm1Ppp Trp53^tm3.1Glo/Trp53⁺ B6.129S7(Cg)-Pml^tm1Ppp Trp53^tm3.1Glo	decreased tumor-free survival time	J:317504
	normal growth/size/body region phenotype	J:317504
	normal hematopoietic system phenotype	J:317504
	hepatosplenomegaly	J:317504
	increased B cell derived lymphoma incidence	J:317504
	increased carcinoma incidence	J:317504
	increased lymphoma incidence	J:317504
	increased osteosarcoma incidence	J:317504
	increased sarcoma incidence	J:317504
	increased T cell derived lymphoma incidence	J:317504
Pml^tm1Ppp/Pml^tm1Ppp Trp53^tm3.1Glo/Trp53^tm3.1Glo B6.129S7(Cg)-Pml^tm1Ppp Trp53^tm3.1Glo	premature death	J:317504
	prenatal lethality, incomplete penetrance	J:317504

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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