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Prrx1 Gene Detail
Summary
  • Symbol
    Prrx1
  • Name
    paired related homeobox 1
  • Synonyms
    A230024N07Rik, K-2, mHox, mHox, MHox1, Pmx1, Prx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97712
    NCBI Gene: 18933
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:163072688-163141279 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 70.53 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    595 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97712
 protein coding gene Chr1:163072688-163142714 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016670
 protein coding gene Chr1:168639417-168706743 (-)
A/J MGP_AJ_G0016651
 protein coding gene Chr1:161756980-161824083 (-)
AKR/J MGP_AKRJ_G0016617
 protein coding gene Chr1:166674576-166745358 (-)
BALB/cJ MGP_BALBcJ_G0016612
 protein coding gene Chr1:162260541-162327754 (-)
C3H/HeJ MGP_C3HHeJ_G0016436
 protein coding gene Chr1:166849768-166917566 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017073
 protein coding gene Chr1:174294278-174363526 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014782
 protein coding gene Chr1:153772934-153840427 (-)
CAST/EiJ MGP_CASTEiJ_G0016016
 protein coding gene Chr1:166507523-166575698 (-)
CBA/J MGP_CBAJ_G0016411
 protein coding gene Chr1:180517418-180586586 (-)
DBA/2J MGP_DBA2J_G0016517
 protein coding gene Chr1:160672110-160738891 (-)
FVB/NJ MGP_FVBNJ_G0016515
 protein coding gene Chr1:159110236-159177767 (-)
LP/J MGP_LPJ_G0016588
 protein coding gene Chr1:169723600-169790313 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016540
 protein coding gene Chr1:188023902-188093563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017109
 protein coding gene Chr1:166483307-166551301 (-)
PWK/PhJ MGP_PWKPhJ_G0015802
 protein coding gene Chr1:159865253-159931969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015589
 protein coding gene Chr1:165385912-165454600 (-)
WSB/EiJ MGP_WSBEiJ_G0016078
 protein coding gene Chr1:166651826-166723398 (-)



Homology
more
  • Human Ortholog
    PRRX1, paired related homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRRX1, paired related homeobox 1
  • Synonyms
    AGOTC, PHOX1, PMX1, PRX1, PRX-1
  • Links
    NCBI Gene ID: 5396
    neXtProt AC: NX_P54821
    UniProt: P54821

  • Chr Location
    1q24.2; chr1:170662728-170739421 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRRX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 4 alleles in 5 genetic backgrounds
    92 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit skeletal defects affecting mandible, limbs, and vertebrae, vascular abnormalities, and neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1550
  • Tissues
    513
  • cDNA Data
    111
  • Literature Summary
    85
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026586 Ensembl Gene Model | MGI Sequence Detail 68592 C57BL/6J ±  kb
    transcript ENSMUST00000027878 Ensembl | MGI Sequence Detail 4952 Not Applicable  
    polypeptide ENSMUSP00000027878 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 6
      cDNA 115
      Primer pair 9
      Other 12

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-13532, MGI:2138130, MGI:2138219, MGI:2138338, MGI:2441785
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 85
      Gene Ontology 17
      Phenotypes 20
    • Earliest
      J:3255 Kern MJ, et al., A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy. Nucleic Acids Res. 1992 Oct 11;20(19):5189-95
    • Latest
      J:343286 Queen R, et al., Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory