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Dlx5 Gene Detail
Summary
  • Symbol
    Dlx5
  • Name
    distal-less homeobox 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:101926
    NCBI Gene: 13395
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:6877801-6882068 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 2.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101926
 protein coding gene Chr6:6877801-6882085 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030441
 protein coding gene Chr6:3797984-3802257 (-)
A/J MGP_AJ_G0030414
 protein coding gene Chr6:3649092-3653375 (-)
AKR/J MGP_AKRJ_G0030341
 protein coding gene Chr6:3755102-3759374 (-)
BALB/cJ MGP_BALBcJ_G0030423
 protein coding gene Chr6:3602222-3606496 (-)
C3H/HeJ MGP_C3HHeJ_G0030137
 protein coding gene Chr6:3692574-3696855 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030878
 protein coding gene Chr6:3887325-3891597 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028089
 protein coding gene Chr6:3269603-3273897 (-)
CAST/EiJ MGP_CASTEiJ_G0029538
 protein coding gene Chr6:3713060-3717344 (-)
CBA/J MGP_CBAJ_G0030115
 protein coding gene Chr6:4027143-4031417 (-)
DBA/2J MGP_DBA2J_G0030259
 protein coding gene Chr6:3589238-3593510 (-)
FVB/NJ MGP_FVBNJ_G0030213
 protein coding gene Chr6:3574935-3581123 (-)
LP/J MGP_LPJ_G0030346
 protein coding gene Chr6:3742188-3746469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030249
 protein coding gene Chr6:4060550-4064826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030908
 protein coding gene Chr6:3693759-3698026 (-)
PWK/PhJ MGP_PWKPhJ_G0029253
 protein coding gene Chr6:3529099-3533446 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029089
 protein coding gene Chr6:3748017-3752298 (-)
WSB/EiJ MGP_WSBEiJ_G0029615
 protein coding gene Chr6:3690987-3695271 (-)



Homology
more
  • Human Ortholog
    DLX5, distal-less homeobox 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLX5, distal-less homeobox 5
  • Synonyms
    SHFM1, SHFM1D
  • Links
    NCBI Gene ID: 1749
    neXtProt AC: NX_P56178
    UniProt: P56178

  • Chr Location
    7q21.3; chr7:97020396-97024950 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dlx5 mouse models; 2 with human DLX5 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    172 phenotypes from 5 alleles in 7 genetic backgrounds
    23 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display multiple defects in craniofacial structures, including ears, nose, mandible and calvaria, and die shortly after birth, with some exhibiting exencephaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1934
  • Tissues
    566
  • cDNA Data
    37
  • Literature Summary
    324
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13395 NCBI Gene Model | MGI Sequence Detail 4268 C57BL/6J ±  kb
    transcript NM_010056 RefSeq | MGI Sequence Detail 1410 Not Specified  
    polypeptide P70396 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      Genomic 1
      cDNA 44
      Primer pair 19
      Other 44

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18757, MGI:2141401
    References
    more
    • Summaries
      All 395
      Developmental Gene Expression 324
      Diseases 2
      Gene Ontology 22
      Phenotypes 60
    • Earliest
      J:17176 Simeone A, et al., Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2250-4
    • Latest
      J:345597 Quilez S, et al., Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory