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Hlf Gene Detail
Summary
  • Symbol
    Hlf
  • Name
    hepatic leukemia factor
  • Synonyms
    E230015K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96108
    NCBI Gene: 217082
  • Gene Overview
    MyGene.info: HLF
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:90336536-90390895 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 55.03 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    371 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96108
protein coding gene Chr11:90336535-90390917 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018938
protein coding gene Chr11:92153886-92213333 (-)
A/J MGP_AJ_G0018906
protein coding gene Chr11:88550604-88605809 (-)
AKR/J MGP_AKRJ_G0018876
protein coding gene Chr11:91275195-91331226 (-)
BALB/cJ MGP_BALBcJ_G0018879
protein coding gene Chr11:88998304-89053282 (-)
C3H/HeJ MGP_C3HHeJ_G0018693
protein coding gene Chr11:91292397-91351044 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019331
protein coding gene Chr11:95039965-95099083 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016962
protein coding gene Chr11:85584290-85639908 (-)
CAST/EiJ MGP_CASTEiJ_G0018248
protein coding gene Chr11:92035481-92093449 (-)
CBA/J MGP_CBAJ_G0018664
protein coding gene Chr11:98988980-99048618 (-)
DBA/2J MGP_DBA2J_G0018772
protein coding gene Chr11:88099113-88153823 (-)
FVB/NJ MGP_FVBNJ_G0018761
protein coding gene Chr11:87613213-87668132 (-)
LP/J MGP_LPJ_G0018842
protein coding gene Chr11:92676795-92732778 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018788
protein coding gene Chr11:98860085-98916660 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019371
protein coding gene Chr11:91523559-91580149 (-)
PWK/PhJ MGP_PWKPhJ_G0018018
protein coding gene Chr11:88994664-89056969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017808
protein coding gene Chr11:91078268-91141934 (-)
WSB/EiJ MGP_WSBEiJ_G0018297
protein coding gene Chr11:91389239-91446032 (-)



Homology
more
  • Human Ortholog
    HLF, HLF transcription factor, PAR bZIP family member
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HLF, HLF transcription factor, PAR bZIP family member
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3131
    neXtProt AC: NX_Q16534
    UniProt: Q16534

  • Chr Location
    17q22; chr17:55264960-55325065 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31074
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HLF
  • Gene Tree
    Hlf
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    27 phenotypes from multigenic genotypes
    20 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003949 Ensembl Gene Model | MGI Sequence Detail 54360 C57BL/6J ±  kb
transcript ENSMUST00000004051 Ensembl | MGI Sequence Detail 5642 Not Applicable  
polypeptide ENSMUSP00000004051 Ensembl | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 62
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10742, MGI:2444586
References
more
  • Summaries
    All 55
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory