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Fcgr3 Gene Detail
Summary
  • Symbol
    Fcgr3
  • Name
    Fc receptor, IgG, low affinity III
  • Synonyms
    CD16, FcgammaRIII, Fcg receptor III
  • Feature Type
    protein coding gene
  • IDs
    MGI:95500
    NCBI Gene: 14131
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:170878743-170892504 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 78.80 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95500
 protein coding gene Chr1:170878738-170893477 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016740
 protein coding gene Chr1:176807636-176826797 (-)
A/J MGP_AJ_G0016720
 protein coding gene Chr1:169592956-169602534 (-)
AKR/J MGP_AKRJ_G0016686
 protein coding gene Chr1:174688209-174714160 (-)
BALB/cJ MGP_BALBcJ_G0016681
 protein coding gene Chr1:170070327-170078884 (-)
C3H/HeJ MGP_C3HHeJ_G0016504
 protein coding gene Chr1:174939450-174950753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017142
 protein coding gene Chr1:182662753-182707677 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0016085
 protein coding gene Chr1:174566464-174575943 (-)
CBA/J MGP_CBAJ_G0016479
 protein coding gene Chr1:189165044-189221367 (-)
DBA/2J MGP_DBA2J_G0016586
 protein coding gene Chr1:168447204-168474777 (-)
FVB/NJ MGP_FVBNJ_G0016582
 protein coding gene Chr1:166806140-166843879 (-)
LP/J MGP_LPJ_G0016657
 protein coding gene Chr1:177927179-177945764 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016609
 protein coding gene Chr1:196449022-196521956 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017179
 protein coding gene Chr1:174571740-174599531 (-)
PWK/PhJ MGP_PWKPhJ_G0015871
 protein coding gene Chr1:167685595-167705976 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015655
 protein coding gene Chr1:173327971-173344547 (-)
WSB/EiJ MGP_WSBEiJ_G0016147
 protein coding gene Chr1:174694476-174704188 (-)



Homology
more
  • Human Ortholog
    FCGR2A, Fc gamma receptor IIa
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCGR2A, Fc gamma receptor IIa
  • Synonyms
    CD32, CD32A, CDw32, FCG2, FcgammaRIIa, FcGR, FCGR2, FCGR2A1, IGFR2
  • Links
    NCBI Gene ID: 2212
    neXtProt AC: NX_P12318
    UniProt: P12318

  • Chr Location
    1q23.3; chr1:161505430-161524048 (+)  GRCh38
Human Diseases
more
  • Diseases
    32 with human FCGR2A,FCGR2B associations

Human Disease Mouse Models
      
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 View 2 models
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    162 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack IgG-mediated mast cell degranulation and have impaired IgG-dependent anaphylaxis and Arthus reactions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    5
  • cDNA Data
    77
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059498 Ensembl Gene Model | MGI Sequence Detail 13762 C57BL/6J ±  kb
    transcript ENSMUST00000164044 Ensembl | MGI Sequence Detail 1347 Not Applicable  
    polypeptide ENSMUSP00000131938 Ensembl | MGI Sequence Detail 267 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 7
      cDNA 77
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-9736
    References
    more
    • Summaries
      All 253
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 162
    • Earliest
      J:8467 Ravetch JV, et al., Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science. 1986 Nov 7;234(4777):718-25
    • Latest
      J:334197 Qiu A, et al., FcgammaRIV is required for IgG2c mediated enhancement of RBC alloimmunization. Front Immunol. 2022;13:972723
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory