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Agtpbp1
Gene Detail
Symbol

Name
ID
Agtpbp1
ATP/GTP binding protein 1
MGI:2159437
Synonyms
1700020N17Rik, 2310001G17Rik, 2900054O13Rik, 4930445M19Rik, 5730402G09Rik, nmf243, Nna1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
31.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr13:59449537-59585227 bp, - strand
From VEGA annotation of GRCm38

  135691 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Agtpbp1

Human
homologs
Human Homolog AGTPBP1, ATP/GTP binding protein 1
NCBI Gene ID 23287
neXtProt AC  NX_Q9UPW5
Human Synonyms  CCP1, NNA1
Human Chr (Location)  9q21.33; chr9:85546539-85742029 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Chemically induced (ENU)(5) Gene trapped(7) Spontaneous(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes show moderate ataxia due to degeneration of Purkinje cells of the cerebellum. Also, there is gradual degeneration of retina photoreceptor cells, olfactory bulb mitral cells and some thalamic neurons. Males have abnormal sperm and are sterile.
 
Human Diseases Modeled Using Mouse Agtpbp1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Agtpbp1 interacts with 347 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process adult walking behavior, cerebellar Purkinje cell differentiation, ...
Component cytoplasm, cytosol, ...
Function carboxypeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (170)    Tissues (49)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 158
RT-PCR 12
cDNA source data(72)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) Genomic(1) cDNA(74) Primer pair(3)
Microarray probesets(7)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035354 VEGA Gene Model | MGI Sequence Detail 135691 C57BL/6J ±  kb
transcript OTTMUST00000090298 VEGA | MGI Sequence Detail 4356 Not Applicable 
polypeptide OTTMUSP00000049503 VEGA | MGI Sequence Detail 1218 Not Applicable 

For the selected sequences
All sequences(195) RefSeq(30) UniProt(21)
Polymorphisms
RFLP(1) : SNPs within 2kb(963 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR000834 Peptidase M14, carboxypeptidase A
Protein Ontology PR:000003848 cytosolic carboxypeptidase 1
References
(Earliest) J:5597 Mullen RJ, et al., Two types of retinal degeneration in cerebellar mutant mice. Nature. 1975 Dec 11;258(5535):528-30
(Latest) J:200027 Berezniuk I, et al., Quantitative peptidomics of Purkinje cell degeneration mice. PLoS One. 2013;8(4):e60981
All references(151)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13173, MGI:1914519, MGI:1916623, MGI:1921986, MGI:1922111, MGI:1923828, MGI:2145471, MGI:97500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory