Sequence Detail

ID/Version

Q641K1 Q8C1K8 Q9EQI4 Q9D962 Q3V147 Q6P9R9 Q3TDS0 (UniProt | EBI)

Last sequence update: 2007-10-23
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Cytosolic carboxypeptidase 1 {ECO:0000303|PubMed:21074048}; EC=3.4.17.- {ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:22170066, ECO:0000269|PubMed:25103237, ECO:0000269|PubMed:29593216, ECO:0000269|PubMed:30420557}; EC=3.4

Provider

SWISS-PROT

Sequence

Polypeptide 1218 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Agtpbp1	ATP/GTP binding protein 1	51	103	3	28

Sequence references in MGI

J:74929 Fernandez-Gonzalez A, et al., Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1. Science. 2002 Mar 8;295(5561):1904-6
J:74936 Harris A, et al., Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases. Mol Cell Neurosci. 2000 Nov;16(5):578-96
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105316 Chakrabarti L, et al., The Purkinje cell degeneration 5J mutation is a single amino acid insertion that destabilizes Nna1 protein. Mamm Genome. 2006 Feb;17(2):103-10
J:116593 Wang T, et al., The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype. Mol Cell Neurosci. 2006 Oct;33(2):200-13
J:120628 Wang T, et al., The Purkinje cell degeneration (pcd) mouse: an unexpected molecular link between neuronal degeneration and regeneration. Brain Res. 2007 Apr 6;1140:26-40
J:163166 Chakrabarti L, et al., Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics. Neuron. 2010 Jun 24;66(6):835-47
J:166837 Rogowski K, et al., A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell. 2010 Nov 12;143(4):564-78
J:167756 Li J, et al., Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-kappaB signaling. Neuron. 2010 Oct 6;68(1):45-60
J:215911 Tort O, et al., The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Mol Biol Cell. 2014 Oct 1;25(19):3017-27
J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261
J:270911 Shashi V, et al., Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. EMBO J. 2018 Dec 3;37(23)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:313952 Berezniuk I, et al., Cytosolic carboxypeptidase 1 is involved in processing alpha- and beta-tubulin. J Biol Chem. 2012 Feb 24;287(9):6503-17