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Pcdh15
Gene Detail
 Symbol
Name
ID
Pcdh15
protocadherin 15
MGI:1891428 		BioType Conflict
Synonyms Gm9815, nmf19, Ush1f
Feature Type protein coding gene
Genetic Map
Chromosome 10
37.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr10:73099342-74646314 bp, + strand
From VEGA annotation of GRCm38

  1546973 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Alleles
and
phenotypes 		All alleles(11) : Gene trapped(2) Transgenic(1) Spontaneous(6) Chemically induced(2)
 
Homozygotes for severe mutations exhibit circling, head-tossing, hyperactivity, impaired swimming and profound deafness. Mice have defects in cochlea and degeneration of hair cells, spiral ganglion cells and saccular macula. Females are poor mothers.
 
Human Diseases Modeled Using Mouse Pcdh15 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications 		All GO classifications: (44 annotations)
Process actin filament organization, adult locomotory behavior, ...
Component cytoplasm, integral to membrane, ...
Function calcium ion binding, protein binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Results (47)    Tissues (41)    Images (16)
Theiler Stages: 20, 22, 24, 25, 26, 28
Assay TypeResults
RNA in situ 40
RT-PCR 7
cDNA source data(25)
External Resources: Allen Institute   ArrayExpress
Molecular
reagents 		All nucleic(28) Genomic(1) cDNA(26) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021142 (Evidence)
Ensembl Gene ModelENSMUSG00000052613 (Evidence), ENSMUSG00000046980 (Evidence)
Entrez Gene11994, 100861952
UniGene338933
DFCITC1595197, TC1667185
DoTSDT.101215277, DT.101327250, DT.484475, DT.55139542, DT.91334909, DT.94178988
NIA Mouse Gene IndexU011651
PDB4APX, 4AQA, 4AQE, 4AXW, 4AQ8
Consensus CDS ProjectCCDS35934.1, CCDS48594.1, CCDS48595.1, CCDS56711.1, CCDS56712.1, CCDS56713.1, CCDS56714.1, CCDS56715.1, CCDS56716.1, CCDS56717.1, CCDS56718.1, CCDS56719.1, CCDS56720.1, CCDS56721.1
International Mouse Knockout Project StatusPcdh15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021142 VEGA Gene Model | MGI Sequence Detail 1546973 C57BL/6J ±  kb
transcript OTTMUST00000050062 VEGA | MGI Sequence Detail 6947 Not Applicable 
polypeptide OTTMUSP00000023313 VEGA | MGI Sequence Detail 1943 Not Applicable 

For the selected sequences
All sequences(176) UniProt(38)
Polymorphisms RFLP(1) : SNPs(2430 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
Protein Ontology PR:000012346 protocadherin-15
References (Earliest) J:14990 Schaible RH, av. Mouse News Lett. 1957;15:29
(Latest) J:193334 Xiong W, et al., TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells. Cell. 2012 Dec 7;151(6):1283-95
All references(74)
Other
accession IDs 		MGD-MRK-1480, MGI:2143894, MGI:2183461, MGI:3710651, MGI:88118
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory