About   Help   FAQ
Tlx3 Gene Detail
Summary
  • Symbol
    Tlx3
  • Name
    T cell leukemia, homeobox 3
  • Synonyms
    Hox11l2, Rnx, Tlx1l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351209
    NCBI Gene: 27140
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:33150752-33153589 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.21 cM, cytoband A5
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351209
 protein coding gene Chr11:33150748-33158588 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018142
 protein coding gene Chr11:31492739-31495576 (-)
A/J MGP_AJ_G0018115
 protein coding gene Chr11:30289819-30292662 (-)
AKR/J MGP_AKRJ_G0018079
 protein coding gene Chr11:31236931-31239770 (-)
BALB/cJ MGP_BALBcJ_G0018084
 protein coding gene Chr11:30462526-30465344 (-)
C3H/HeJ MGP_C3HHeJ_G0017897
 protein coding gene Chr11:31177875-31180720 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018538
 protein coding gene Chr11:32508219-32511056 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016193
 protein coding gene Chr11:28790765-28793575 (-)
CAST/EiJ MGP_CASTEiJ_G0017461
 protein coding gene Chr11:31250260-31253124 (-)
CBA/J MGP_CBAJ_G0017870
 protein coding gene Chr11:34068961-34071800 (-)
DBA/2J MGP_DBA2J_G0017980
 protein coding gene Chr11:30057313-30060156 (-)
FVB/NJ MGP_FVBNJ_G0017974
 protein coding gene Chr11:29887774-29890619 (-)
LP/J MGP_LPJ_G0018052
 protein coding gene Chr11:31751361-31754179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017998
 protein coding gene Chr11:35016218-35019067 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018577
 protein coding gene Chr11:31378858-31381678 (-)
PWK/PhJ MGP_PWKPhJ_G0017242
 protein coding gene Chr11:30238274-30241122 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017034
 protein coding gene Chr11:31098177-31101020 (-)
WSB/EiJ MGP_WSBEiJ_G0017510
 protein coding gene Chr11:31001606-31004452 (-)



Homology
more
  • Human Ortholog
    TLX3, T cell leukemia homeobox 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLX3, T cell leukemia homeobox 3
  • Synonyms
    HOX11L2, RNX
  • Links
    NCBI Gene ID: 30012
    neXtProt AC: NX_O43711
    UniProt: O43711

  • Chr Location
    5q35.1; chr5:171309248-171312139 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tlx3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die within 1 day of birth due to a central respiratory failure that resembles human congenital central hypoventilation syndrome. Mice homozygous for an ENU-induced allele exhibit uncoordinated movements.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    132
  • cDNA Data
    12
  • Literature Summary
    81
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040610 Ensembl Gene Model | MGI Sequence Detail 2838 C57BL/6J ±  kb
    transcript ENSMUST00000037746 Ensembl | MGI Sequence Detail 1533 Not Applicable  
    polypeptide ENSMUSP00000047457 Ensembl | MGI Sequence Detail 291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 3
      cDNA 12
      Primer pair 1
      Other 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 81
      Diseases 2
      Gene Ontology 11
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:343072 Vermeiren S, et al., Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia. iScience. 2023 Dec 15;26(12):108364
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory