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Etv6
Gene Detail
Symbol

Name
ID
Etv6
ets variant 6
MGI:109336
Synonyms
Tel, translocation-ets-leukemia
Feature Type
protein coding gene
Genetic Map
Chromosome 6
64.58 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:134035700-134270158 bp, + strand
From VEGA annotation of GRCm38

  234459 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Etv6

Human
homologs
Human Homolog ETV6, ets variant 6
NCBI Gene ID 2120
neXtProt AC  NX_P41212
Human Synonyms  TEL, TEL/ABL
Human Chr (Location)  12p13; chr12:11649854-11895402 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(134) : Gene trapped(127) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit defective yolk sac angiogenesis, excess apoptosis of mesenchymal and neural cells, and midgestational lethality.
 
Interactions
Etv6 interacts with 364 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell differentiation, negative regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, nucleolus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (294)    Tissues (245)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 278
RT-PCR 16
cDNA source data(150)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(157) Genomic(1) cDNA(153) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025993 (Evidence)
Ensembl Gene ModelENSMUSG00000030199 (Evidence)
Entrez Gene14011 (Evidence)
UniGene269995
DoTSDT.40181926, DT.110493580, DT.110493502, DT.535237, DT.99841130
NIA Mouse Gene IndexU042770
PDB4MHG, 2LF8, 2LF7, 2MD5
Consensus CDS ProjectCCDS39677.1
International Mouse Knockout Project StatusEtv6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025993 VEGA Gene Model | MGI Sequence Detail 234459 C57BL/6J ±  kb
transcript OTTMUST00000064123 VEGA | MGI Sequence Detail 5548 Not Applicable 
polypeptide OTTMUSP00000031804 VEGA | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(6) UniProt(17)
Polymorphisms
RFLP(1) : SNPs within 2kb(2739 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2743)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007229 transcription factor ETV6
References
(Earliest) J:38299 Depatie C, et al., High-resolution linkage map in the proximity of the host resistance locus Cmv1. Genomics. 1997 Jan 15;39(2):154-63
(Latest) J:179397 Schachterle W, et al., ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol. 2012 Jan 15;361(2):439-49
All references(69)
Other
accession IDs
MGD-MRK-38381, MGI:2141650, MGI:2141710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory