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a Gene Detail
Summary
  • Symbol
    a
  • Name
    nonagouti
  • Synonyms
    agouti, agouti signal protein, As, Asip, ASP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87853
    NCBI Gene: 50518
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:154792519-154892932 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 76.83 cM
  • Mapping Data
    299 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2726 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87853
 protein coding gene Chr2:154633322-154892932 (+)
129S1/SvImJ ENSMUSG00200027633
 protein coding gene Chr2:151498260-151759537 (+)
A/J ENSMUSG00195020395
 protein coding gene Chr2:151861268-152120653 (+)
AKR/J ENSMUSG00220043643
 protein coding gene Chr2:151150767-151410209 (+)
BALB/cJ ENSMUSG00180038616
 protein coding gene Chr2:151326404-151587592 (+)
C3H/HeJ ENSMUSG00175038281
 protein coding gene Chr2:152070536-152331720 (+)
C57BL/6NJ ENSMUSG00215026257
 protein coding gene Chr2:151481056-151740436 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024520
 protein coding gene Chr2:146729083-146995929 (+)
CAST/EiJ ENSTCUG00005041922
 protein coding gene Chr2:150481367-150731323 (+)
CBA/J ENSMUSG00210036240
 protein coding gene Chr2:152007043-152268209 (+)
DBA/2J ENSMUSG00185046156
 protein coding gene Chr2:151694365-151953730 (+)
FVB/NJ ENSMUSG00205034733
 protein coding gene Chr2:150773334-151034596 (+)
JF1/MsJ ENSUMUG00000022567
 protein coding gene Chr2:151350269-151609704 (+)
LP/J ENSMUSG00230042001
 protein coding gene Chr2:153534354-153557429 (+)
NOD/ShiLtJ ENSMUSG00190037000
 protein coding gene Chr2:151395967-151657131 (+)
NZO/HlLtJ ENSMUSG00225004472
 protein coding gene Chr2:161568160-161591270 (+)
PWK/PhJ ENSLUMG00010035206
 protein coding gene Chr2:151294140-151561106 (+)
SPRET/EiJ ENSMSPG00010028414
 protein coding gene Chr2:154108975-154358754 (+)
WSB/EiJ ENSIUOG00005042128
 protein coding gene Chr2:151093469-151354603 (+)



Homology
more
  • Human Ortholog
    ASIP, agouti signaling protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASIP, agouti signaling protein
  • Synonyms
    AGSW, AGTI, AGTIL, ASP, SHEP9
  • Links
    NCBI Gene ID: 434
    UniProt: P42127

  • Chr Location
    20q11.22; chr20:34186493-34269346 (+)  GRCh38
  • MGI Vertebrate Homology
    a stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: ASIP
  • Gene Tree
    a
Human Diseases
more
  • Diseases
    2 with a mouse models; 1 with human ASIP associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 86 alleles in 47 genetic backgrounds
    141 phenotypes from multigenic genotypes
    11 images
    502 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Agouti acts in the hair follicles, primarily affecting the relative amount and distribution of yellow pigment (phaeomelanin) and black pigment (eumelanin) in hairs of the coat. Some alleles show lethal effects or are associated with obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    11
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50518 NCBI Gene Model | MGI Sequence Detail 100414 C57BL/6J ±  kb
    transcript NM_015770 RefSeq | MGI Sequence Detail 692 Not Specified  
    polypeptide Q03288 UniProt | EBI | MGI Sequence Detail 131 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 43
      cDNA 16
      Primer pair 2
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1002, MGD-MRK-1008, MGD-MRK-1397
    References
    more
    • Summaries
      All 742
      Developmental Gene Expression 7
      Diseases 9
      Gene Ontology 17
      Phenotypes 502
    • Earliest
      J:15011 Dunn LC, A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A. 1928 Oct;14(10):816-9
    • Latest
      J:387447 Kawarizadeh K, et al., VPS33B regulates MHC class II antigen presentation in dendritic cells to drive CD4 T cell immunity. iScience. 2026 Jun 19;29(6):116052
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory