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Ppp5c
Gene Detail
Symbol

Name
ID
Ppp5c
protein phosphatase 5, catalytic subunit
MGI:102666
Synonyms
ANP receptor, PP5
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:17004640-17027924 bp, - strand
From VEGA annotation of GRCm38

  23285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4550  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPP5C
Protein SuperFamily: protein phosphatase 5
Gene Tree: Ppp5c

Human
homologs
PPP5C, protein phosphatase 5, catalytic subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5536
neXtProt AC: NX_P53041

Human Synonyms: PP5, PPP5, PPT

Human Chr (Location): 19q13.3; chr19:46346994-46390975 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(19) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit a decrease in cell cycle check-point arrest following treatment with ionizing radition.
 
Interactions
Ppp5c interacts with 74 markers (Mir17, Mir20b, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process histone dephosphorylation, negative regulation of cell death, ...
Component cell periphery, cytoplasm, ...
Function G-protein alpha-subunit binding, heat shock protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ppp5c ; ZFIN ppp5c    NEW 
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016479 (Evidence)
Ensembl Gene Model ENSMUSG00000003099 (Evidence)
Entrez Gene 19060 (Evidence)
DFCI TC1573554
DoTS DT.110993253, DT.110993235, DT.101268549, DT.535209
NIA Mouse Gene Index U028196
EC 3.1.3.16
Consensus CDS Project CCDS20859.1
International Mouse Phenotyping Consortium Status Ppp5c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016479 VEGA Gene Model | MGI Sequence Detail 23285 C57BL/6J ±  kb
transcript OTTMUST00000039755 VEGA | MGI Sequence Detail 2072 Not Applicable 
polypeptide OTTMUSP00000017740 VEGA | MGI Sequence Detail 499 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR013235 PPP domain
InterPro IPR011236 Serine/threonine protein phosphatase 5
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000013157 serine/threonine-protein phosphatase 5
References
(Earliest) J:21536 Chinkers M, Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11075-9
(Latest) J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24
All references(46)
Other
accession IDs
MGD-MRK-19567, MGI:2142135

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory