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Ppp5c
Gene Detail
 Symbol
Name
ID
Ppp5c
protein phosphatase 5, catalytic subunit
MGI:102666
Synonyms ANP receptor, PP5
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:17004640-17027924 bp, - strand
From VEGA annotation of GRCm38

  23285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4550  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: protein phosphatase 5
Gene Tree: Ppp5c

Human
homologs
Human Homolog PPP5C, protein phosphatase 5, catalytic subunit
NCBI Gene ID 5536
neXtProt AC  NX_P53041
Human Synonyms  PP5, PPP5, PPT
Human Chr (Location)  19q13.3; chr19:46346994-46390975 (+)  GRCh38
Alleles
and
phenotypes
All alleles(24) : Gene trapped(19) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit a decrease in cell cycle check-point arrest following treatment with ionizing radition.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process dephosphorylation, positive regulation of I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, cytosol, ...
Function hydrolase activity, identical protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016479 (Evidence)
Ensembl Gene ModelENSMUSG00000003099 (Evidence)
Entrez Gene19060 (Evidence)
DFCITC1573554
DoTSDT.101268549, DT.110993235, DT.110993253, DT.535209
NIA Mouse Gene IndexU028196
EC3.1.3.16
Consensus CDS ProjectCCDS20859.1
International Mouse Knockout Project StatusPpp5c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016479 VEGA Gene Model | MGI Sequence Detail 23285 C57BL/6J ±  kb
transcript OTTMUST00000039755 VEGA | MGI Sequence Detail 2072 Not Applicable 
polypeptide OTTMUSP00000017740 VEGA | MGI Sequence Detail 499 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR013235 PPP domain
InterPro IPR011236 Serine/threonine protein phosphatase 5
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000013157 serine/threonine-protein phosphatase 5
References (Earliest) J:21536 Chinkers M, Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11075-9
(Latest) J:206164 Grankvist N, et al., Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain. FEBS Lett. 2013 Nov 29;587(23):3869-74
All references(45)
Other
accession IDs
MGD-MRK-19567, MGI:2142135

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory