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Rheb Gene Detail
Summary
  • Symbol
    Rheb
  • Name
    Ras homolog enriched in brain
  • Synonyms
    Rheb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97912
    NCBI Gene: 19744
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:25007821-25047359 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 11.93 cM
Strain
Comparison
more
  • SNPs within 2kb
    1124 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97912
 protein coding gene Chr5:25007821-25047622 (-)
129S1/SvImJ ENSMUSG00200012736
 protein coding gene Chr5:20609741-20649572 (-)
A/J ENSMUSG00195038485
 protein coding gene Chr5:20078705-20118491 (-)
AKR/J ENSMUSG00220033935
 protein coding gene Chr5:20161345-20201103 (-)
BALB/cJ ENSMUSG00180019878
 protein coding gene Chr5:19952810-19992618 (-)
C3H/HeJ ENSMUSG00175046668
 protein coding gene Chr5:21876895-21916681 (-)
C57BL/6NJ ENSMUSG00215040348
 protein coding gene Chr5:20520155-20559957 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027024
 protein coding gene Chr5:19699367-19739756 (-)
CAST/EiJ ENSTCUG00005003026
 protein coding gene Chr5:20089405-20129039 (-)
CBA/J ENSMUSG00210044792
 protein coding gene Chr5:20916185-20955970 (-)
DBA/2J ENSMUSG00185035642
 protein coding gene Chr5:22455143-22494252 (-)
FVB/NJ ENSMUSG00205030284
 protein coding gene Chr5:19723818-19763625 (-)
JF1/MsJ ENSUMUG00000003393
 protein coding gene Chr5:27017993-27057109 (-)
LP/J ENSMUSG00230023325
 protein coding gene Chr5:26891705-26931536 (-)
NOD/ShiLtJ ENSMUSG00190004888
 protein coding gene Chr5:20004234-20044018 (-)
NZO/HlLtJ ENSMUSG00225017006
 protein coding gene Chr5:32308521-32348215 (-)
PWK/PhJ ENSLUMG00010033244
 protein coding gene Chr5:20055002-20094765 (-)
SPRET/EiJ ENSMSPG00010032717
 protein coding gene Chr5:20915436-20955318 (-)
WSB/EiJ ENSIUOG00005036379
 protein coding gene Chr5:22814929-22854629 (-)



Homology
more
  • Human Ortholog
    RHEB, Ras homolog, mTORC1 binding
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHEB, Ras homolog, mTORC1 binding
  • Synonyms
    RHEB2
  • Links
    NCBI Gene ID: 6009
    UniProt: Q15382

  • Chr Location
    7q36.1; chr7:151466012-151520120 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 5 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality during organogenesis associated with impaired heart development. Mice homozygous for a conditional allele activated in the heart exhibit postnatal lethality due to impaired cardiac hypertrophic growth and sarcomere maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    668
  • Tissues
    41
  • cDNA Data
    133
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19744 NCBI Gene Model | MGI Sequence Detail 39539 C57BL/6J ±  kb
    transcript NM_053075 RefSeq | MGI Sequence Detail 1521 C57BL/6  
    polypeptide Q921J2 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 135
      cDNA 133
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-13864
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 18
      Phenotypes 65
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391267 Zhang X, et al., Characterization and application of hyperthermia-evoked seizures in a mouse model of focal cortical dysplasia. Neurobiol Dis. 2026 Apr 20;:107405
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory