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Mmp2 Gene Detail
Summary
  • Symbol
    Mmp2
  • Name
    matrix metallopeptidase 2
  • Synonyms
    72kDa gelatinase, 72kDa type IV collagenase, Clg4a, GelA, gelatinase A, MMP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97009
    NCBI Gene: 17390
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:93553920-93580049 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97009
 protein coding gene Chr8:93553919-93580049 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033936
 protein coding gene Chr8:94142333-94170213 (+)
A/J MGP_AJ_G0033919
 protein coding gene Chr8:90430669-90456397 (+)
AKR/J MGP_AKRJ_G0033845
 protein coding gene Chr8:92973187-92999586 (+)
BALB/cJ MGP_BALBcJ_G0033911
 protein coding gene Chr8:90585431-90611787 (+)
C3H/HeJ MGP_C3HHeJ_G0033621
 protein coding gene Chr8:93688247-93714915 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034432
 protein coding gene Chr8:97609424-97637355 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031373
 protein coding gene Chr8:84354184-84384521 (+)
CAST/EiJ MGP_CASTEiJ_G0032953
 protein coding gene Chr8:93245083-93273704 (+)
CBA/J MGP_CBAJ_G0033597
 protein coding gene Chr8:100852692-100884038 (+)
DBA/2J MGP_DBA2J_G0033751
 protein coding gene Chr8:89974556-90001366 (+)
FVB/NJ MGP_FVBNJ_G0033698
 protein coding gene Chr8:88914194-88940563 (+)
LP/J MGP_LPJ_G0033843
 protein coding gene Chr8:94256075-94290857 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033740
 protein coding gene Chr8:103212607-103237412 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034450
 protein coding gene Chr8:93089605-93116905 (+)
PWK/PhJ MGP_PWKPhJ_G0032655
 protein coding gene Chr8:89325032-89351636 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032492
 protein coding gene Chr8:91938960-91966060 (+)
WSB/EiJ MGP_WSBEiJ_G0033065
 protein coding gene Chr8:93551082-93577894 (+)



Homology
more
  • Human Ortholog
    MMP2, matrix metallopeptidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP2, matrix metallopeptidase 2
  • Synonyms
    CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1
  • Links
    NCBI Gene ID: 4313
    neXtProt AC: NX_P08253
    UniProt: P08253

  • Chr Location
    16q12.2; chr16:55389700-55506691 (+)  GRCh38
Human Diseases
more
  • Diseases
    11 with human MMP2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 2 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    1 images
    137 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit slightly delayed growth, reduced neovascularization, retarded tumor progression, an exaggerated asthma response to allergens, and impaired branching morphogenesis of the mammary gland.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1000
  • Tissues
    171
  • cDNA Data
    174
  • Literature Summary
    120
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17390 NCBI Gene Model | MGI Sequence Detail 26130 C57BL/6J ±  kb
    transcript NM_008610 RefSeq | MGI Sequence Detail 3078 ZRU/MplStud  
    polypeptide P33434 UniProt | EBI | MGI Sequence Detail 662 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      cDNA 174
      Primer pair 16
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12279, MGD-MRK-2013
    References
    more
    • Summaries
      All 403
      Developmental Gene Expression 120
      Gene Ontology 19
      Phenotypes 137
    • Earliest
      J:218 Bennett D, Brain hernia, a new recessive mutation in the mouse. J Hered. 1959;50(6):265-8
    • Latest
      J:343523 Kalev-Altman R, et al., Mmp2 Deficiency Leads to Defective Parturition and High Dystocia Rates in Mice. Int J Mol Sci. 2023 Nov 27;24(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory