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Itgal
Gene Detail
 Symbol
Name
ID
Itgal
integrin alpha L
MGI:96606
Synonyms Cd11a, LFA-1, Ly-15, Ly-21
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr7:127296260-127335137 bp, + strand
From VEGA annotation of GRCm38

  38878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1666  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgal

Human
homologs
Human Homolog ITGAL, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
NCBI Gene ID 3683
neXtProt AC  NX_P20701
Human Synonyms  CD11A, LFA-1, LFA1A
Human Chr (Location)  16p11.2; chr16:30472662-30523185 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations of this gene lead to increased leukocyte cell number, alter T cell activation, leukocyte migration and adhesion, spleen and lymph node morphology, and may affect humoral immune responses, metastatic potential, and susceptibility to endotoxin shock.
 
Interactions
Itgal interacts with 201 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process activated T cell proliferation, cell adhesion, ...
Component cell-cell junction, cell surface, ...
Function cell adhesion molecule binding, ICAM-3 receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (4)    Tissues (1)    Images (4)
Theiler Stages: 23
Assay TypeResults
RNA in situ 4
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(40) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031314 (Evidence)
Ensembl Gene ModelENSMUSG00000030830 (Evidence)
Entrez Gene16408 (Evidence)
UniGene1618
DFCITC1581814, TC1629001
DoTSDT.101217713, DT.111003971, DT.40185440, DT.99853078
NIA Mouse Gene IndexU008797
Consensus CDS ProjectCCDS57588.1, CCDS57589.1
International Mouse Knockout Project StatusItgal
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031314 VEGA Gene Model | MGI Sequence Detail 38878 C57BL/6J ±  kb
transcript OTTMUST00000077570 VEGA | MGI Sequence Detail 4533 Not Applicable 
polypeptide OTTMUSP00000041058 VEGA | MGI Sequence Detail 1201 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(14) UniProt(15)
Polymorphisms PCR(1) : SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001011 integrin alpha-L
References (Earliest) J:6511 Potter TA, et al., Ly-15: a new murine lymphocyte alloantigenic locus. Transplantation. 1981 May;31(5):339-42
(Latest) J:209590 Li J, et al., Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest. 2014 Apr 1;124(4):1483-96
All references(149)
Other
accession IDs
MGD-MRK-11485, MGD-MRK-11953, MGD-MRK-11960, MGD-MRK-1830

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory