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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itgal
integrin alpha L
MGI:96606
42 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itgalem1(IMPC)H/Itgalem1(IMPC)H
C57BL/6NTac-Itgalem1(IMPC)H/H 		increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
Itgaltm1.1Mshi/Itgaltm1.1Mshi
involves: C57BL/6 		abnormal diapedesis J:168533
abnormal leukocyte adhesion J:168533
abnormal leukocyte migration J:168533
decreased lymphocyte cell number J:168533
enhanced leukocyte tethering or rolling J:168533
small lymph nodes J:168533
Itgaltm1Bll/Itgal+
involves: 129S7/SvEvBrd 		abnormal CD4-positive, alpha-beta T cell physiology J:267548
Itgaltm1Bll/Itgaltm1Bll
B6.129S7-Itgaltm1Bll 		abnormal leukocyte adhesion J:100242
abnormal leukocyte tethering or rolling J:100242
decreased T cell proliferation J:90954
impaired natural killer cell mediated cytotoxicity J:90954
increased leukocyte cell number J:100242
increased neutrophil cell number J:100242
Itgaltm1Bll/Itgaltm1Bll
B6.129S7-Itgaltm1Bll/J 		abnormal inflammatory response J:113463
Itgaltm1Bll/Itgaltm1Bll
involves: 129S7/SvEvBrd 		abnormal CD4-positive, alpha-beta T cell physiology J:267548
abnormal cellular extravasation J:141063
abnormal leukocyte adhesion J:141063
abnormal neutrophil physiology J:141063
Itgaltm1Bll/Itgaltm1Bll
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal cellular extravasation J:83226
abnormal leukocyte adhesion J:83226
abnormal leukocyte migration J:83226
increased eosinophil cell number J:83226
increased leukocyte cell number J:83226
increased monocyte cell number J:83226
increased neutrophil cell number J:83226
Itgaltm1Hlz/Itgaltm1Hlz
involves: 129P2/OlaHsd 		abnormal cellular extravasation J:99286
abnormal humoral immune response J:99286
abnormal leukocyte adhesion J:99286
abnormal T cell activation J:99286
decreased cytotoxic T cell cytolysis J:99286
decreased lymphocyte cell number J:99286
decreased neutrophil cell number J:99286
spleen hyperplasia J:99286
Itgaltm1Hogg/Itgaltm1Hogg
involves: 129P2/OlaHsd 		abnormal leukocyte adhesion J:82587
abnormal leukocyte migration J:82587
abnormal lymph node morphology J:82587
decreased B cell number J:82587
decreased CD4-positive, alpha-beta T cell number J:82587
decreased CD8-positive, alpha-beta T cell number J:82587
decreased lymphocyte cell number J:82587
enlarged spleen J:82587
increased CD4-positive, alpha-beta T cell number J:82587
increased CD8-positive, alpha-beta T cell number J:82587
small lymph nodes J:82587
Itgaltm1Mak/Itgal+
B6.129P2-Itgaltm1Mak 		decreased susceptibility to endotoxin shock J:123460
Itgaltm1Mak/Itgaltm1Mak
B6.129P2-Itgaltm1Mak 		decreased susceptibility to endotoxin shock J:123460
impaired natural killer cell mediated cytotoxicity J:110889
increased circulating interleukin-2 level J:123460
increased circulating interleukin-10 level J:123460
increased circulating tumor necrosis factor level J:123460
thrombocytopenia J:123460
Itgaltm1Wpfl/Itgaltm1Wpfl
involves: 129 		abnormal cytotoxic T cell physiology J:37160
abnormal leukocyte physiology J:37160
abnormal lymphocyte physiology J:37160
normal immune system phenotype J:37160
increased metastatic potential J:37160
lymph node hyperplasia J:37160
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory