Itgal^tm1Hogg
Targeted Allele Detail

Summary

• Symbol: Itgal^tm1Hogg
• Name: integrin alpha L; targeted mutation 1, Nancy Hogg
• MGI ID: MGI:2655183
• Synonyms: LFA-1^-
• Gene: Itgal Location: Chr7:126895432-126934310 bp, + strand Genetic Position: Chr7, 69.44 cM
• Alliance: Itgal^tm1Hogg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82587
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a cassette containing lacZ and neo. Surface expression was undetected on leukocytes obtained from homozygous mutant mice. (J:82587)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgal Mutation: 74 strains or lines available

References

• Original: J:82587 Berlin-Rufenach C, et al., Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J Exp Med. 1999 May 3;189(9):1467-78
• All: 10 reference(s)