Phenotypes associated with this allele

• Allele Symbol: Itgal^tm1Hogg
• Allele Name: targeted mutation 1, Nancy Hogg
• Allele ID: MGI:2655183
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgal^tm1Hogg/Itgal^tm1Hogg	involves: 129P2/OlaHsd	MGI:2655184

Genotype
MGI:2655184

hm1

• Allelic Composition: Itgal^tm1Hogg/Itgal^tm1Hogg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:82587 )

• homing experiments show that lymphocytes migrate into peripheral lymph nodes, mesenteric lymph nodes and Peyer's Patches with 21, 51, and 68% of the efficiency of wild-type lymphocytes, resulting in increased numbers in the spleens

abnormal leukocyte adhesion ( J:82587 )

• circulating lymphocytes exhibit limited adhesion to lymph node high endothelial venules (HEVs)

enlarged spleen ( J:82587 )

increased CD4-positive, alpha-beta T cell number ( J:82587 )

• significant increase in the spleen

increased CD8-positive, alpha-beta T cell number ( J:82587 )

• significant increase in the spleen

decreased lymphocyte cell number ( J:82587 )

• peripheral lymph nodes contain ~70% fewer lymphocytes than those of wild-type littermates

decreased B cell number ( J:82587 )

• in the peripheral lymph nodes

decreased CD4-positive, alpha-beta T cell number ( J:82587 )

• substantial loss of CD4+ T cells in the peripheral lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:82587 )

• substantial loss of CD8+ T cells in the peripheral lymph nodes

abnormal lymph node morphology ( J:82587 )

• peripheral lymph nodes contain ~70% fewer lymphocytes than those of wild-type littermates

small lymph nodes ( J:82587 )

• decrease in size of peripheral lymph nodes, however other lymph nodes are normal sized

hematopoietic system

abnormal leukocyte migration ( J:82587 )

• homing experiments show that lymphocytes migrate into peripheral lymph nodes, mesenteric lymph nodes and Peyer's Patches with 21, 51, and 68% of the efficiency of wild-type lymphocytes, resulting in increased numbers in the spleens

abnormal leukocyte adhesion ( J:82587 )

• circulating lymphocytes exhibit limited adhesion to lymph node high endothelial venules (HEVs)

enlarged spleen ( J:82587 )

increased CD4-positive, alpha-beta T cell number ( J:82587 )

• significant increase in the spleen

increased CD8-positive, alpha-beta T cell number ( J:82587 )

• significant increase in the spleen

decreased lymphocyte cell number ( J:82587 )

• peripheral lymph nodes contain ~70% fewer lymphocytes than those of wild-type littermates

decreased B cell number ( J:82587 )

• in the peripheral lymph nodes

decreased CD4-positive, alpha-beta T cell number ( J:82587 )

• substantial loss of CD4+ T cells in the peripheral lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:82587 )

• substantial loss of CD8+ T cells in the peripheral lymph nodes

cellular

abnormal leukocyte migration ( J:82587 )

• homing experiments show that lymphocytes migrate into peripheral lymph nodes, mesenteric lymph nodes and Peyer's Patches with 21, 51, and 68% of the efficiency of wild-type lymphocytes, resulting in increased numbers in the spleens

abnormal leukocyte adhesion ( J:82587 )

• circulating lymphocytes exhibit limited adhesion to lymph node high endothelial venules (HEVs)

growth/size/body

enlarged spleen ( J:82587 )